RTECS:DS2800000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Beryllium fluoride

RTECS #: DS2800000

CAS #: 7787-49-7

UPDATE: May 2005 MW: 47.01 MF: BeF₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Beryllium difluoride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 20 痢/m³/1 hour/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors GTPZAB 19(7),34,1975
inhalation
rat toxic concentration (other than lowest) : 49 痢/m³/26 week Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors PEXTAR 2,203,1961

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
hamster lethal dose (50 percent kill): 21 mg/kg N/R XEURAQ UR-154,1951
intravenous
mouse lethal dose (50 percent kill): 1,800 痢/kg N/R XPHPAW 2173,23,1972
oral
mouse lethal dose (50 percent kill): 100 mg/kg N/R XPHPAW 2173,23,1972
oral
rat lethal dose (50 percent kill): 98 mg/kg N/R XEURAQ UR-154,1951
subcutaneous
mouse lethal dose (50 percent kill): 20 mg/kg N/R XPHPAW 2173,23,1972

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
cat lowest published toxic concentration: 10 mg/m³/6 hour/30 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AMIHBC 8,493,1953
inhalation
dog lowest published toxic concentration: 1 mg/m³/6 hour/30 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHBC 8,493,1953
inhalation
guinea pig lowest published toxic concentration: 10 mg/m³/6 hour/30 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHBC 8,493,1953
inhalation
mammal (species unspecified) lowest published toxic concentration: 1.1 mg/m³/6 hour/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,95,1988
inhalation
mouse lowest published toxic concentration: 10 mg/m³/6 hour/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHBC 8,493,1953
inhalation
rat lowest published toxic concentration: 1 mg/m³/6 hour/30 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHBC 8,493,1953
inhalation
rat lowest published toxic concentration: 0.4 mg(Be)/m³/1 hour/16 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,95,1988
inhalation
rat lowest published toxic concentration: 0.4 mg(Be)/m³/1 hour/78 week- intermittent Lung, Thorax, or Respiration: Bronchogenic carcinoma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,95,1988
inhalation
rabbit lowest published toxic concentration: 1 mg/m³/6 hour/30 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes AMIHBC 8,493,1953
inhalation
rabbit lowest published toxic concentration: 2.2 mg/m³/23 week- intermittent Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,95,1988

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Be)/m³ DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m³ DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 23,143,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,41,1993
TOXICOLOGY REVIEW
CTOXAO 6,497,1973
TOXICOLOGY REVIEW
AMIHBC 8,1,1953

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Be)/m³ CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.5 mg(F)/m³ CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Be)/m³ CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2.5 mg(F)/m³ CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Be)/m³ CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2.5 mg(F)/m³ CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Be)/m³ CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2.5 mg(F)/m³ CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.002 mg(Be)/m³, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.002 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m³, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - AUSTRIA MAK 2.5 mg(F)/m³, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m³, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.001 mg(Be)/m³, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m³, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.002 mg(Be)/m³, short term exposure limit 0.006 mg(Be)/m³, Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(F)/m³, JAN1999
Occupational Exposure Limit - FRANCE VME 0.002 mg(Be)/m³, continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 2.5 mg(F)/m³, JAN1999
Occupational Exposure Limit - GERMANY MAK 2.5 mg(F)/m³, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.001 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg(F)/m³, short term exposure limit 2 mg(F)/m³, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.002 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.002 mg(Be)/m³, 2A Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.001 mg(Be)/m³, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg(F)/m³, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg(Be)/m³, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2.5 mg(F)/m³, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.001 mg(Be)/m³, MAC(short term exposure limit) 0.002 mg(Be)/m³, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m³, MAC(short term exposure limit) 3 mg(HF)/m³, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.001 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - SWEDEN NGV 2 mg(F)/m³, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.002 mg(Be)/m³, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg(Be)/m³, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1.8 ppm (1.5 mg(F)/m³), KZG- week 1.8 ppm (3.0 mg(F)/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.002 mg(Be)/m³, short term exposure limit 0.005 mg(Be)/m³, JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 2.5 mg(F)/m³, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.002 mg(Be)/m³, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 2.5 mg(F)/m³, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.002 mg(Be)/m³, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 2.5 mg(F)/m³, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.002 mg(Be)/m³, Carcinogen, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m³, SEP2000

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air Carcinogen not to exceed 0.0005 mg(Be)/m³ NIOSH* DHHS #92-100,1992

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in production of BERYLLIUM and its alloys
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen

REFERENCES:
CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. (Rochester, NY)
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-

Used as an intermediate in production of BERYLLIUM and its alloys

RTECS Compound Description:
Tumorigen

ALT CAS #: 12323-05-6
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