The Registry of Toxic Effects of Chemical Substances

Beryllium

RTECS #: DS1750000

CAS #: 7440-41-7

UPDATE: May 2005 MW: 9.01 MF: Be


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Beryllium - 9
  2. Beryllium (ACGIH:OSHA)
  3. RCRA waste number P015
  1. Glucinium
  2. Glucinum


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct Escherichia coli 30 µmol/L MUREAV 89,95,1981
DNA adduct human HeLa cell 30 µmol/L MUREAV 89,95,1981
DNA adduct mouse Ascites tumor 30 µmol/L MUREAV 89,95,1981
DNA inhibition intravenous
non-mammalian species 		30 µmol/kg PHMCAA 12,298,1970


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
rat 		lowest published toxic dose: 13 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		ENVRAL 21,63,1980
intravenous
rabbit 		lowest published toxic dose: 20 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors 		LANCAO 1,463,1950


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
rat 		lethal dose (50 percent kill): 51 mg/kg N/R STGNBT -,23,1999
intravenous
rat 		lethal dose (50 percent kill): 496 µg/kg Liver: Hepatitis (hepatocellular necrosis), zonal LAINAW 15,176,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 2 µg/m3/8 hour/26 week- intermittent Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes 		FEREAC 67,70707,2002
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 20 ng/m3/1 hour/17 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		STGNBT -,23,1999
inhalation
rat 		lowest published toxic concentration: 20 ng/m3/8 hour/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins 		STGNBT -,23,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Be)/m3;short term exposure limit 0.01 mg(Be)/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 1,17,1972
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 23,143,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 23,143,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,41,1993
TOXICOLOGY REVIEW
CRTXB2 1,235,1972
TOXICOLOGY REVIEW
85CVA2 5,63,1970
TOXICOLOGY REVIEW
CTOXAO 6,497,1973
TOXICOLOGY REVIEW
AEMBAP 40,239,1973
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
NTIS** CONF-691001
TOXICOLOGY REVIEW
AMTODM 3,209,1977
TOXICOLOGY REVIEW
SCIEAS 201,298,1978
TOXICOLOGY REVIEW
TOLED5 127,63,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.002 mg/m3 DTLVS* 3,24,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.002 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.002 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg/m3, Carcinogen JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.001 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.002 mg/m3, short term exposure limit 0.006 mg/m3, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.002 mg/m3, continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.001 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.002 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.002 mg/m3, 2A Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.001 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.001 mg/m3, MAC(short term exposure limit) 0.003 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.001 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.002 mg/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg/m3, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.002 mg/m3, short term exposure limit 0.005 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.002 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.002 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air Carcinogen not to exceed 0.0005 mg(Be)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 11770;
Number of Industries 8;
Total Number of Facilities 344;
Number of Occupations 17;
Total Number of Employees Exposed 10,510
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 11770;
Number of Industries 22;
Total Number of Facilities 421;
Number of Occupations 29;
Total Number of Employees Exposed 13,938;
Total Number of Female Employees Exposed 739


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182392/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacturing for electrical components, nuclear reactors and in aerospace industry
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Beryllium and compounds, as Be, 7102
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID125G


REFERENCES:

CODEN
REFERENCE
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1952-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used in manufacturing for electrical components, nuclear reactors and in aerospace industry

NIOSH PROFILE (SMELTERS, SECONDARY NON-FERROUS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen

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