The Registry of Toxic Effects of Chemical Substances
Benzoyl chloride |
UPDATE: May 2004 | MW: 140.57 | MF: C7H5ClO |
SYNONYMS: | |
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
mutation in microorganisms | Salmonella typhimurium | 1 痠ol/plate (+enzymatic activation step) | MUREAV 58,11,1978 |
mutation in microorganisms | Salmonella typhimurium | 5 mg/plate (-enzymatic activation step) | TSCAT* FYI-OTS-1180-0107 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
skin mouse | lowest published toxic dose: 9,200 mg/kg/50 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors | GANNA2 72,655,1981 |
skin mouse | toxic dose : 17,600 mg/kg/42 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors | GANNA2 72,655,1981 |
skin mouse | toxic dose : 35,200 mg/kg/42 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | GANNA2 72,655,1981 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation human | lowest published toxic concentration: 2 ppm/1 minute |
Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes | TGNCDL 2,31,1961 |
inhalation rat | lethal concentration (50 percent kill): 1,870 mg/m3/2 hour | N/R | 85GMAT -,25,1982 |
oral rat | lethal dose (50 percent kill): 1,900 mg/kg | N/R | TSCAT* FYI-OTS-1180-0107 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Not Classifiable as a Human Carcinogen | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | ceiling concentration 0.5 ppm | DTLVS* TLV/BEI,2003 |
International Agency for Research on Cancer (IARC) Cancer Review | Human Limited Evidence | IMEMDT 71,453,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Inadequate Evidence | IMEMDT 29,83,1982 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Inadequate Evidence | IMEMDT 71,453,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Human Inadequate Evidence | IMEMDT 29,83,1982 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 3 | IMSUDL 7,56,1987 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - HUNGARY | time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1993 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 5 mg/m3, JAN1993 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 81724; Number of Industries 5; Total Number of Facilities 117; Number of Occupations 6; Total Number of Employees Exposed 1,008 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 81724![]() Number of Industries 5; Total Number of Facilities 148; Number of Occupations 30; Total Number of Employees Exposed 6,871; Total Number of Female Employees Exposed 2,826 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
Used as a chemical intermediate | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
85GMAT | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
GANNA2 | Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
IMSUDL | IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
TGNCDL | "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961 |
TSCAT* | Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) |