The Registry of Toxic Effects of Chemical Substances
1H - Benzotriazole |
UPDATE: November 2004 | MW: 119.14 | MF: C6H5N3 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
mutation in microorganisms | Escherichia coli | 33,300 ng/plate (+enzymatic activation step) | ENMUDM 7(Suppl 5),1,1985 |
mutation in microorganisms | Salmonella typhimurium | 100 痢/plate (-enzymatic activation step) | IAPUDO 27,283,1980 |
morphological transform | rat embryo | 94 痢/plate | JJATDK 1,190,1981 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral mouse | lowest published toxic dose: 770 gm/kg/78 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma | NCITR* NCI-TR-88,1978 |
oral rat | lowest published toxic dose: 220 gm/kg/78 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Brain and Coverings: Tumors | NCITR* NCI-TR-88,1978 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lethal concentration (50 percent kill): 1,910 mg/m3/3 hour |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | NTIS** OTS0520637 |
intraperitoneal mouse | lethal dose (50 percent kill): 400 mg/kg | N/R | FATOAO 41,708,1978 |
intravenous mouse | lethal dose (50 percent kill): 238 mg/kg | N/R | JPETAB 105,486,1952 |
oral guinea pig | lethal dose (50 percent kill): 500 mg/kg |
Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Cyanosis | GISAAA 46(11),70,1981 |
oral mouse | lethal dose (50 percent kill): 615 mg/kg | N/R | NTIS** AD-A067-313 |
oral rat | lethal dose (50 percent kill): 560 mg/kg | N/R | NTIS** OTS0516797 |
skin rat | lethal dose (50 percent kill): >1 gm/kg | N/R | NTIS** OTS0516745 |
skin rabbit | lowest published lethal dose: 450 mg/kg | N/R | NTIS** OTS0520182 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral rat | lowest published toxic dose: 109 mg/kg/26 week- intermittent |
Endocrine: Other changes Blood: Normocytic anemia Blood: Luekopenia | GISAAA 46(11),70,1981 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
TOXICOLOGY REVIEW |
| MUREAV 543,201,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - RUSSIA | short term exposure limit 5 mg/m3, Skin, JAN1993 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 82113; Number of Industries 23; Total Number of Facilities 1,661; Number of Occupations 33; Total Number of Employees Exposed 5,550 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 82113![]() Number of Industries 144; Total Number of Facilities 17,143; Number of Occupations 107; Total Number of Employees Exposed 279,549; Total Number of Female Employees Exposed 40,869 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as cutting and lubricating oils, antifreezes, and corrosion inhibitor for copper/brass | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat | NCITR* NCI-TR-88,1978 |
REFERENCES: | |
CODEN |
REFERENCE |
ENMUDM | Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. |
FATOAO | Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
IAPUDO | IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979- |
JJATDK | JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- |
JPETAB | Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NCITR* | National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |