The Registry of Toxic Effects of Chemical Substances

1H - Benzotriazole

RTECS #: DM1225000

CAS #: 95-14-7

UPDATE: November 2004 MW: 119.14 MF: C6H5N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2, - Aminozophenylene
  2. Azimidobenzene
  3. Aziminobenzene
  4. Benzisotriazole
  5. Benzene azimide
  6. 1,2,3 - Benzotriazole
  7. 2,3 - Diazaindole
  1. NCI - C03521
  2. 1,2,3 - Triazaindene
  3. Benztriazole
  4. Cobratec #99
  5. NSC - 3058
  6. U - 6233


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 33,300 ng/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) IAPUDO 27,283,1980
morphological transform rat embryo 94 µg/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 770 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		NCITR* NCI-TR-88,1978
oral
rat 		lowest published toxic dose: 220 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors 		NCITR* NCI-TR-88,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,910 mg/m3/3 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0520637
intraperitoneal
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R FATOAO 41,708,1978
intravenous
mouse 		lethal dose (50 percent kill): 238 mg/kg N/R JPETAB 105,486,1952
oral
guinea pig 		lethal dose (50 percent kill): 500 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis 		GISAAA 46(11),70,1981
oral
mouse 		lethal dose (50 percent kill): 615 mg/kg N/R NTIS** AD-A067-313
oral
rat 		lethal dose (50 percent kill): 560 mg/kg N/R NTIS** OTS0516797
skin
rat 		lethal dose (50 percent kill): >1 gm/kg N/R NTIS** OTS0516745
skin
rabbit 		lowest published lethal dose: 450 mg/kg N/R NTIS** OTS0520182


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 109 mg/kg/26 week- intermittent Endocrine: Other changes

Blood: Normocytic anemia

Blood: Luekopenia 		GISAAA 46(11),70,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82113;
Number of Industries 23;
Total Number of Facilities 1,661;
Number of Occupations 33;
Total Number of Employees Exposed 5,550
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82113;
Number of Industries 144;
Total Number of Facilities 17,143;
Number of Occupations 107;
Total Number of Employees Exposed 279,549;
Total Number of Female Employees Exposed 40,869


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as cutting and lubricating oils, antifreezes, and corrosion inhibitor for copper/brass
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat NCITR* NCI-TR-88,1978


REFERENCES:

CODEN
REFERENCE
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as cutting and lubricating oils, antifreezes, and corrosion inhibitor for copper/brass

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

ALT CAS #: 25377-81-5
ALT CAS #: 27556-51-0
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