The Registry of Toxic Effects of Chemical Substances

Benzothiazole, 2,2' - dithiobis -

RTECS #: DL4550000

CAS #: 120-78-5

UPDATE: April 1998 MW: 332.48 MF: C14H8N2S4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Altax
  2. Benzothiazole disulfide
  3. Benzothiazolyl disulfide
  4. 2 - Benzothiazolyl disulfide
  5. Bis (benzothiazolyl) disulfide
  6. Bis (2 - benzothiazyl) disulfide
  7. MBTS
  8. MBTS rubber accelerator
  9. 2 - Mercaptobenzothiazole disulfide
  10. 2 - Mercaptobenzothiazyl disulfide
  11. Benzothiazyl disulfide
  12. Dibenzothiazolyl disulphide
  13. Di - 2 - benzothiazolyl disulfide
  1. Dibenzothiazyl disulfide
  2. 2,2' - Dibenzothiazyl disulfide
  3. Dibenzoylthiazyl disulfide
  4. Dibenzthiazyl disulfide
  5. 2,2' - Dithiobis (benzothiazole)
  6. Dwusiarczek dwubenzotiazylu (Polish)
  7. Royal MBTS
  8. Thiofide
  9. USAF CY - 5
  10. USAF EK - 5432
  11. Vulkacit DM
  12. Vulkacit DM/mgc


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms mouse lymphocyte 15 mg/L (+enzymatic activation step) ENMUDM 5,193,1983
mutation in microorganisms Salmonella typhimurium 3,333 µg/plate (+/-enzymatic activation step) EMMUEG 11(Suppl 12),1,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
parenteral
rat 		lowest published toxic dose: 400 mg/kg (4-11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		BEXBAN 93,107,1982
parenteral
rat 		lowest published toxic dose: 400 mg/kg (4-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BEXBAN 93,107,1982
parenteral
rat 		lowest published toxic dose: 800 mg/kg (2 day male/2 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		BEXBAN 93,107,1982
parenteral
rat 		lowest published toxic dose: 800 mg/kg (2 day male/2 day prior to copulation) Reproductive: Effects on embryo or fetus: Fetal death BEXBAN 93,107,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 172 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 2,600 mg/kg N/R IPSTB3 3,93,1976
intravenous
mouse 		lethal dose (50 percent kill): 180 mg/kg N/R CSLNX* NX#02251
oral
mouse 		lethal dose (50 percent kill): 7 gm/kg N/R IPSTB3 3,93,1976
oral
rat 		lethal dose (50 percent kill): >12 gm/kg N/R NTIS** AD755-358
skin
rabbit 		lethal dose (50 percent kill): >7,940 mg/kg N/R EPASR* 8EHQ-1190-0987S


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 9,100 mg/kg/13 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		KHZDAN 23,414,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84830;
Number of Industries 12;
Total Number of Facilities 897;
Number of Occupations 28;
Total Number of Employees Exposed 11,180
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84830;
Number of Industries 19;
Total Number of Facilities 1,533;
Number of Occupations 42;
Total Number of Employees Exposed 50,590;
Total Number of Female Employees Exposed 11,091


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as vulcanization accelerator in rubber products
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as vulcanization accelerator in rubber products

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

 Click Here for Additional Information about RTECS