The Registry of Toxic Effects of Chemical Substances

p - Benzoquinone, 2,3,5,6 - tetrachloro -

RTECS #: DK6825000

CAS #: 118-75-2

UPDATE: February 2003 MW: 245.86 MF: C6Cl4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Spergon
  2. Spergon I
  3. Spergon technical
  4. 1,4 - Benzoquinone, 2,3,5,6 - tetrachloro -
  5. Chloranil
  6. Dow Seed Disinfectant No. 5
  7. ENT 3,797
  8. G - 25804
  9. G - 444E
  10. Geigy - 444E
  1. Reranil
  2. Tetrachlorobenzoquinone
  3. Tetrachloro - p - benzoquinone
  4. Tetrachloro - 1,4 - benzoquinone
  5. 2,3,5,6 - Tetrachloro - p - benzoquinone
  6. 2,3,5,6 - Tetrachloro - 1,4 - benzoquinone
  7. 2,3,5,6 - Tetrachloro - 2,5 - cyclohexadiene - 1,4 - dione
  8. Tetrachloroquinone
  9. Tetrachloro - p - quinone
  10. Vulklor


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human fibroblast 50 µmol/L/1 hour MUREAV 513,159,2002
mutation in microorganisms Salmonella typhimurium 1,100 nmol/plate (+enzymatic activation step) MUREAV 347,37,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 71 gm/kg/78 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 2,485 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0530657-1
intraperitoneal
rat 		lethal dose (50 percent kill): 500 mg/kg N/R PHBUA9 3,337,1955
oral
rat 		lethal dose (50 percent kill): 4 gm/kg N/R PCOC** -,218,1966
unreported route
rat 		lethal dose (50 percent kill): 8,450 mg/kg N/R GISAAA 37(5),15,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 15 gm/kg/8 day- intermittent Behavioral: Food intake (animal)

Blood: Change in clotting factors

Blood: Changes in leukocyte (WBC) count 		JIHTAB 25,98,1943
oral
rat 		lowest published toxic dose: 66,956 mg/kg/22 week- continuous Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JIHTAB 25,98,1943
oral
rat 		lowest published toxic dose: 49,915 mg/kg/67 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 25,98,1943


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84201;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 2;
Total Number of Employees Exposed 41
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84201;
Number of Industries 3;
Total Number of Facilities 125;
Number of Occupations 8;
Total Number of Employees Exposed 2,098;
Total Number of Female Employees Exposed 761


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as catalyst for polymerization
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For publisher information, see CPBTAL.

Used as catalyst for polymerization

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen

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