The Registry of Toxic Effects of Chemical Substances

Benzonitrile, 2,6 - dichloro -

RTECS #: DI3500000

CAS #: 1194-65-6

UPDATE: August 2003 MW: 172.01 MF: C7H3Cl2N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Casoron
  2. Casoron 133
  3. Cyclomec
  4. 2,6 - DBN
  5. DBN (the herbicide)
  6. Decabane
  7. H 133
  8. H 1313
  9. NIA 5996
  1. Niagara 5,996
  2. Code H 133
  3. 2,6 - Dichlorbenzonitril (German)
  4. Dichlobenil
  5. 2,6 - Dichlorobenzonitrile
  6. DU - Sprex
  7. Norosac
  8. Prefix D


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 260 µg/kg/39 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		AAATAP 122,107,1979
subcutaneous
mouse 		lowest published toxic dose: 260 µg/kg/39 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application 		AAATAP 122,107,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 360 mg/kg N/R FRPSAX 41,41,1986
oral
guinea pig 		lethal dose (50 percent kill): 681 mg/kg N/R PCOC** -,337,1966
oral
mouse 		lethal dose (50 percent kill): 2,056 mg/kg N/R 28ZEAL 5,73,1976
oral
rat 		lethal dose (50 percent kill): 2,710 mg/kg N/R RREVAH 10,97,1965
oral
rabbit 		lethal dose (50 percent kill): 270 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Other changes 		FCTXAV 6,261,1968
skin
mouse 		lethal dose : >200 mg/kg Olfaction: Deviated nasal septum

Olfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Lipids including transport 		NRTXDN 15,287,1994
skin
rabbit 		lethal dose (50 percent kill): 1,350 mg/kg N/R GUCHAZ 6,177,1973
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1 gm/kg N/R 30ZDA9 -,144,1971
unreported route
rat 		lethal dose (50 percent kill): 500 mg/kg N/R 30ZDA9 -,145,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 1 gm/kg/5 day- intermittent Olfaction: Deviated nasal septum

Olfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Lipids including transport 		NRTXDN 15,287,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DTTIAF 80,485,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,111,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24030;
Number of Industries 1;
Total Number of Facilities 40;
Number of Occupations 1;
Total Number of Employees Exposed 200


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
Used as selective herbicide of vineyards and common herbicide of playgrounds
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-

Used as selective herbicide of vineyards and common herbicide of playgrounds

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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