The Registry of Toxic Effects of Chemical Substances

Benzonitrile

RTECS #: DI2450000

CAS #: 100-47-0

UPDATE: July 2000 MW: 103.13 MF: C7H5N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzenenitrile
  2. Benzoic acid nitrile
  3. Benzene, cyano -
  1. Cyanobenzene
  2. Fenylkyanid (Czech)
  3. Phenyl cyanide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,723,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		168 ppm MUREAV 403,149,1998
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 1,580 mg/L MUREAV 241,255,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 1,800 mg/m3 N/R GTPZAB 21(6),34,1977
inhalation
rat 		lowest published lethal concentration: 950 ppm/8 hour Lung, Thorax, or Respiration: Other changes AMRL** TR-74-78,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R FCTXAV 17,723,1979
intraperitoneal
rat 		lethal dose (50 percent kill): 740 mg/kg Eye: Ptosis

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Acute pulmonary edema 		APFRAD 48,23,1990
intraperitoneal
rabbit 		lethal dose (50 percent kill): 1,250 mg/kg N/R FCTXAV 17,723,1979
oral
cat 		lethal dose (50 percent kill): 800 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		FCTXAV 17,723,1979
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 800 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse 		lethal dose (50 percent kill): 971 mg/kg N/R NEZAAQ 39,423,1984
oral
rat 		lowest published lethal dose: 720 mg/kg N/R AMRL** TR-74-78,1974
oral
rabbit 		lethal dose (50 percent kill): 800 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		FCTXAV 17,723,1979
subcutaneous
frog 		lowest published lethal dose: 1,700 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea 		AIPTAK 5,161,1899
subcutaneous
pigeon 		lowest published lethal dose: 500 mg/kg N/R FCTXAV 17,723,1979
subcutaneous
rabbit 		lowest published lethal dose: 200 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		AIPTAK 5,161,1899
skin
rat 		lethal dose (50 percent kill): 1,200 mg/kg N/R AMRL** TR-74-78,1974
skin
rabbit 		lethal dose (50 percent kill): 1,250 mg/kg N/R FCTXAV 17,723,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 70 mg/m3/4 hour/19 week- intermittent Liver: Liver function tests impaired

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		GTPZAB 21(3),40,1977
inhalation
rabbit 		lowest published toxic concentration: 70 mg/m3/4 hour/19 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain GTPZAB 21(6),34,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1153;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 34


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as electroplating agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-

Used as electroplating agent

NIOSH PROFILE (NITRILES), SRC, 10/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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