The Registry of Toxic Effects of Chemical Substances

Benzilic acid, 4,4' - dichloro - , ethyl ester

RTECS #: DD2275000

CAS #: 510-15-6

UPDATE: August 2003 MW: 325.20 MF: C16H14Cl2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. AKAR
  2. AKAR 50
  3. AKAR 338
  4. Benzilan
  5. ACAR
  6. Acaraben
  7. Acaraben 4E
  8. Benzeneacetic acid, 4 - chloro - alpha - (4 - chlorophenyl) - alpha - hydroxy - , ethyl ester
  9. Benz - O - chlor
  10. Kop - mite
  11. NCI - C00408
  12. NCI - C60413
  13. RCRA waste number U038
  14. Chlorbenzilat
  15. Chlorbenzilate
  16. Chlorbenzylate
  17. Chlorobenzilate
  18. Chlorobenzylate
  1. Compound 338
  2. 4,4' - Dichlorbenzilsaeureaethylester (German)
  3. 4,4' - Dichlorobenzilate
  4. 4,4' - Dichlorobenzilic acid ethyl ester
  5. ENT 18,596
  6. Ethyl 4 - chloro - alpha - (4 - chlorophenyl) - alpha - hydroxybenzeneacetate
  7. Ethyl p,p' - dichlorobenzilate
  8. Ethyl 4,4' - dichlorobenzilate
  9. Ethyl 4,4' - dichlorodiphenyl glycollate
  10. Ethyl 4,4' - dichlorophenyl glycollate
  11. Ethyl ester of 4,4' - dichlorobenzilic acid
  12. Ethylester kyseliny 4,4 - dichlorbenzilove (Czech)
  13. Ethyl - 2 - hydroxy - 2,2 - bis (4 - chlorophenyl) acetate
  14. Folbex
  15. Folbex smoke - strips
  16. G 338
  17. G 23992
  18. Geigy 338


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		25 mg moderate CIGET* -,-,1977
skin
rabbit 		125 mg open irritation test mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms mouse lymphocyte 70 mg/L (+enzymatic activation step) EMMUEG 12,85,1988
mutation in mammalian somatic cells mouse lymphocyte 80 mg/L EMMUEG 12,85,1988
morphological transform oral
rat 		4,620 mg/kg/77 day- continuous CRNGDP 11,1413,1990
other mutation test systems Escherichia coli 12,010 nmol/L EMMUEG 19,98,1992
other mutation test systems oral
mouse 		360 mg/kg MUREAV 343,157,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 71 gm/kg/82 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease 		JNCIAM 42,1101,1969
oral
mouse 		toxic dose : 210 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-75,1978
oral
mouse 		toxic dose : 125 gm/kg/83 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		DIGEBW 16,308,1977
oral
rat 		lowest published toxic dose: 5,475 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors 		CTOXAO 16,67,1980
oral
rat 		toxic dose : 17,520 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors 		CTOXAO 16,67,1980
oral
rat 		toxic dose : 72 gm/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-75,1978
oral
rat 		toxic dose : 1,752 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors

Skin and Appendages: Tumors 		CTOXAO 16,67,1980


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lethal dose (50 percent kill): 700 mg/kg N/R TXAPA9 48,A192,1979
oral
mouse 		lethal dose (50 percent kill): 700 mg/kg N/R HBPTO* 2,1342,2001
oral
rat 		lethal dose (50 percent kill): 700 mg/kg N/R HBPTO* 2,1342,2001
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R TXAPA9 14,515,1969
skin
rabbit 		lethal dose (50 percent kill): >1 gm/kg N/R SPEADM 78-1,15,1978
unreported route
mouse 		lethal dose (50 percent kill): 729 mg/kg N/R 30ZDA9 -,141,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,200 mg/kg/17 week- intermittent Immunological Including Allergic: Decrease in cellular immune response FATOAO 35(3),352,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 30,73,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,73,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
85CVA2 5,250,1970
TOXICOLOGY REVIEW
CTOXAO 13,231,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,98,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an acaricide in agricultural applications
On EPA IRIS database
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse NCITR* NCI-TR-75,1978
NCI Carcinogenesis Bioassay (feed);inadequate studies:rat NCITR* NCI-TR-75,1978


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DIGEBW Digestion. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1968-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an acaricide in agricultural applications

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Primary Irritant

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