The Registry of Toxic Effects of Chemical Substances

Benzenethiol

RTECS #: DC0525000

CAS #: 108-98-5

UPDATE: November 2004 MW: 110.18 MF: C6H6S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Mercaptobenzene
  2. Phenol, thio -
  3. Phenyl mercaptan
  4. Phenyl mercaptan (ACGIH:OSHA)
  1. RCRA waste number P014
  2. Thiofenol (Czech)
  3. Thiophenol
  4. USAF XR - 19


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		108 mg severe AIHAAP 19,171,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other effects to embryo or fetus 		NTIS** PB94-155009
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female NTIS** PB94-155009
oral
rat 		lowest published toxic dose: 18 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 18 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 315 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 5,145 mg/kg (21 week prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 9 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 9 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB94-155009
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** #PB94-155009
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Other effects to embryo or fetus NTIS** #PB94-155009


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 28 ppm/4 hour Lung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation 		AIHAAP 19,171,1958
inhalation
rat 		lethal concentration (50 percent kill): 33 ppm/4 hour Lung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation 		AIHAAP 19,171,1958
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 9,800 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		AIHAAP 19,171,1958
oral
wild bird 		lethal dose (50 percent kill): 24 mg/kg N/R TXAPA9 21,315,1972
oral
mouse 		lethal dose (50 percent kill): 267 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		NTIS** OTS0557376
oral
mouse 		lethal dose (50 percent kill): 266 mg/kg N/R GISAAA 1,7,1994
oral
rat 		lethal dose (50 percent kill): 46,200 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		AIHAAP 19,171,1958
oral
rat 		lethal dose (50 percent kill): 223 mg/kg N/R GISAAA 1,7,1994
skin
rat 		lethal dose (50 percent kill): 300 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Primary irritation 		AIHAAP 19,171,1958
skin
rabbit 		lethal dose (50 percent kill): 134 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		AIHAAP 19,171,1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 27 mg/kg/30 day- intermittent Cardiac: EKG changes not diagnostic of above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 1,7,1994
oral
rat 		lowest published toxic dose: 1.825 mg/kg/26 week- intermittent Behavioral: Change in motor activity (specific assay)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 1,7,1994
oral
rat 		lowest published toxic dose: 18.25 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases GISAAA 1,7,1994
oral
rat 		lowest published toxic dose: 5,145 mg/kg/21 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 1,323 mg/kg/21 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 1,323 mg/kg/21 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 1,323 mg/kg/21 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 2,646 mg/kg/21 week- intermittent Liver: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 200 mg/kg/10 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB94-155009
oral
rat 		lowest published toxic dose: 500 mg/kg/10 day- intermittent Behavioral: Fluid intake

Liver: Changes in liver weight 		NTIS** #PB94-155009
oral
rabbit 		lowest published toxic dose: 420 mg/kg/14 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB94-201183
oral
rabbit 		lowest published toxic dose: 700 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB94-155009
skin
rabbit 		lowest published toxic dose: 500 µL/kg/5 day- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0557376


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2.3 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.3 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.5 ppm (2.6 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (2.3 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BENZENETHIOL-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4092;
Number of Industries 1;
Total Number of Facilities 24;
Number of Occupations 2;
Total Number of Employees Exposed 879;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, solvent, and mosquito larvicide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a chemical intermediate, solvent, and mosquito larvicide

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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