The Registry of Toxic Effects of Chemical Substances

Benzene, 1,2,3 - trimethyl -

RTECS #: DC3300000

CAS #: 526-73-8

UPDATE: November 2004 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,2,3 - Trimethylbenzene
  2. 1,2,3 - Trimethylbenzene (ACGIH)
  1. Hemimellitene
  2. Hemimellitol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 5 µg/plate (-enzymatic activation step) MUREAV 412,299,1998
sister chromatid exchange intraperitoneal
mouse 		730 mg/kg MUREAV 412,299,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published lethal dose: 10 mL/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		AMIHAB 19,403,1959


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/20 day- intermittent Behavioral: Alteration of classical conditioning NRTXDN 22,79,2001
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/16 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition VCVGH* -,176,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (125 mg/m3), SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1997;
Number of Industries 2;
Total Number of Facilities 13;
Number of Occupations 2;
Total Number of Employees Exposed 279


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as raw material in chemical synthesis and as ultraviolet stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as raw material in chemical synthesis and as ultraviolet stabilizer

NIOSH PROFILE (TRIMETHYL BENZENES), SRC, 1/81

RTECS Compound Description:
   Mutagen

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