The Registry of Toxic Effects of Chemical Substances
1,2,4,5 Benzenetetracarboxylic 1,2:4,5 dianhydride |
UPDATE: September 2000 | MW: 218.12 | MF: C10H2O6 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 50 mg | severe | TPKVAL 14,125,1975 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published lethal concentration: 150 mg/m3/4 hour | N/R | 85GMAT -,105,1982 |
oral guinea pig | lethal dose (50 percent kill): 1,595 mg/kg |
Behavioral: Excitement Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | GISAAA 51(11),79,1986 |
oral mouse | lethal dose (50 percent kill): 2,400 mg/kg |
Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Muscle weakness | TPKVAL 14,125,1975 |
oral rat | lethal dose (50 percent kill): 2,250 mg/kg |
Behavioral: Excitement Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | GISAAA 51(11),79,1986 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 20 mg/m3/17 week- intermittent |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Respiratory depression Liver: Fatty liver degeneration | TPKVAL 14,125,1975 |
oral rat | lowest published toxic dose: 1,320 mg/kg/30 day- intermittent |
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | GISAAA 51(11),79,1986 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 84105; Number of Industries 6; Total Number of Facilities 62; Number of Occupations 9; Total Number of Employees Exposed 721 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 84105; Number of Industries 4; Total Number of Facilities 64; Number of Occupations 3; Total Number of Employees Exposed 1,926; Total Number of Female Employees Exposed 728 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
85GMAT | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
TPKVAL | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- |