The Registry of Toxic Effects of Chemical Substances

Benzene, pentachloronitro -

RTECS #: DA6650000

CAS #: 82-68-8

UPDATE: February 2005 MW: 295.32 MF: C6Cl5NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Avicol (pesticide)
  2. Avicolreg
  3. Batrilex
  4. Benzene, nitropentachloro -
  5. Botrilex
  6. Botrilexreg
  7. Brassicol
  8. Brassicol 75
  9. Brassicol super
  10. Brassicolreg
  11. Chinozan
  12. Earthcide
  13. Fartox
  14. Folosan
  15. Folosanreg
  16. Fomac 2
  17. Fungiclor
  18. GC 3944 - 3 - 4
  19. HOE 026014
  20. Kobutol
  21. Marisan forte
  22. NCI - C00419
  23. Olpisan
  24. PCNB
  1. PKhNB
  2. PKhNb
  3. Pentachlornitrobenzol (German)
  4. Pentachloronitrobenzene
  5. Pentachloronitrobenzene (ACGIH)
  6. Pentagen
  7. Quinosan
  8. Quintocene
  9. Quintozen
  10. Quintozene
  11. RCRA waste number U185
  12. RTU 1010
  13. Saniclor 30
  14. Terrachlor
  15. Terraclor
  16. Terraclorreg
  17. Terrafun
  18. Terrazan
  19. Tilcarex
  20. Tilcarexreg
  21. Tri - pcnb
  22. Tritisan
  23. Tritosanreg


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 7,500 µg/L EMMUEG 10(Suppl 10),1,1987
DNA adduct Escherichia coli 20 µmol/L MUREAV 89,95,1981
DNA repair Salmonella typhimurium 1 mg/disc JPFCD2 21,319,1986
mutation in microorganisms Aspergillus nidulans 5 µmol/L (-enzymatic activation step) PHYTAJ 66,217,1976
mutation in microorganisms Escherichia coli 10 mg/plate (-enzymatic activation step) MUREAV 11,247,1971
gene conversion and mitotic recombination Aspergillus nidulans 40 µmol/L MUREAV 147,288,1985
sex chromosome loss and nondisjunction Aspergillus nidulans 17 µmol/L EVHPAZ 31,81,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5 gm/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on embryo or fetus: Fetal death 		TXAPA9 35,239,1976
oral
mouse 		lowest published toxic dose: 1,935 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** PB223-160
oral
mouse 		lowest published toxic dose: 4,176 mg/kg (6-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		NTIS** PB223-160
oral
mouse 		lowest published toxic dose: 4,176 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 135 gm/kg/77 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		JNCIAM 42,1101,1969


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 2 gm/m3 N/R 85GMAT -,96,1982
inhalation
rat 		lethal concentration (50 percent kill): 1,400 mg/m3 N/R 85GMAT -,96,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 4,500 mg/kg N/R ARTODN 51,329,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 5 gm/kg N/R 85INA8 5,462.1(89),1986
oral
dog 		lethal dose : >2,500 mg/kg Gastrointestinal: Nausea or vomiting AIPTAK 114,38,1958
oral
mouse 		lethal dose (50 percent kill): 1,400 mg/kg N/R 85GMAT -,96,1982
oral
rat 		lethal dose (50 percent kill): 1,100 mg/kg N/R FAATDF 7,299,1986
oral
rabbit 		lethal dose (50 percent kill): 800 mg/kg N/R AIPTAK 114,38,1958
skin
rabbit 		lethal dose : >4 gm/kg N/R TXAPA9 18,522,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published toxic dose: 62,660 mg/kg/30 day- continuous Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** PB288-416
oral
mouse 		lowest published toxic dose: 13,650 mg/kg/13 week- intermittent Liver: Changes in liver weight NTPTR* NTP-TR-325,1987
oral
rat 		lowest published toxic dose: 11,250 mg/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AIPTAK 114,38,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 5,211,1974
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 5,211,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
85CVA2 5,250,1970
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,140,1998
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0806;
Number of Industries 1;
Total Number of Facilities 18;
Number of Occupations 1;
Total Number of Employees Exposed 18
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0806;
Number of Industries 1;
Total Number of Facilities 38;
Number of Occupations 2;
Total Number of Employees Exposed 574;
Total Number of Female Employees Exposed 77


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: TRP reversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a soil fungicide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse
NTP Carcinogenesis Studies (feed);no evidence:mouse NTPTR* NTP-TR-325,1987


REFERENCES:

CODEN
REFERENCE
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHYTAJ Phytopathology. (American Phytopathological Soc., 3340 Pilot Knob Rd., St. Paul, MN 55121) V.1- 1911-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a soil fungicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 39378-26-2
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