The Registry of Toxic Effects of Chemical Substances

Benzene, isocyanato -

RTECS #: DA3675000

CAS #: 103-71-9

UPDATE: February 2005 MW: 119.13 MF: C7H5NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Carbanil
  2. Isocyanic acid, phenyl ester
  3. Karbanil (Czech)
  4. Fenylisokyanat (Czech)
  1. Mondur P
  2. Phenylcarbimide
  3. Phenyl carbonimide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) ABCHA6 44,3017,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 22 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cyanosis 		NTIS** OTS0530489
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis 		NTIS** OTS0528337
intraperitoneal
rat 		lethal dose (50 percent kill): 100 mg/kg Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		NTIS** OTS0528337
oral
mouse 		lethal dose (50 percent kill): 196 mg/kg N/R EESADV 17,258,1989
oral
rat 		lethal dose (50 percent kill): 800 mg/kg Eye: Other eye effects

Behavioral: Somnolence (general depressed activity) 		NTIS** OTS0528337
subcutaneous
mouse 		lethal dose (50 percent kill): 1,400 mg/kg N/R YAKUD5 9,759,1967
skin
rat 		lethal dose (50 percent kill): 5 mL/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Aggression

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0528430
skin
rabbit 		lethal dose (50 percent kill): 7,130 mg/kg N/R TXAPA9 42,417,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 7 mg/m3/6 hour/2 week- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Blood: Changes in erythrocyte (RBC) count 		FAATDF 24,217,1995
inhalation
rat 		lowest published toxic concentration: 500 ppb/6 hour/3 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Pigmented or nucleated red blood cells

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0528433


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TOLED5 140-141,183,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83340;
Number of Industries 4;
Total Number of Facilities 79;
Number of Occupations 7;
Total Number of Employees Exposed 325
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83340;
Number of Industries 4;
Total Number of Facilities 161;
Number of Occupations 5;
Total Number of Employees Exposed 1,453;
Total Number of Female Employees Exposed 474


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9105;8EHQ-0892-9121
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

NIOSH PROFILE (ISOCYANATES, ORGANIC), SRC, 10/77

RTECS Compound Description:
   Mutagen

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