The Registry of Toxic Effects of Chemical Substances
Benzene, 2,6 - diisocyanato - 1 - methyl - |
UPDATE: May 2005 | MW: 174.17 | MF: C9H6N2O2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster ovary | 600 mg/L | EMMUEG 13,133,1989 |
mutation in microorganisms | Salmonella typhimurium | 10 痢/plate (-enzymatic activation step) | NTPTR* NTP-TR-251,1986 |
mutation in microorganisms | Salmonella typhimurium | 300 痢/plate (+enzymatic activation step) | MUREAV 438,109,1999 |
morphological transform | mouse fibroblast | 20 mg/L/21 day (-enzymatic activation step) | EMMUEG 37,231,2001 |
sister chromatid exchange | hamster ovary | 300 mg/L | EMMUEG 13,133,1989 |
specific locus test | mouse lymphocyte | 25 mg/L | EMMUEG 17,196,1991 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation human | lowest published toxic concentration: 50 ppb |
Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes | ATXKA8 19,364,1962 |
oral wild bird | lethal dose (50 percent kill): 100 mg/kg | N/R | AECTCV 12,355,1983 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.005 ppm; short term exposure limit 0.02 ppm | DTLVS* TLV/BEI,1999 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Not classifiable as a human carcinogen | DTLVS* TLV/BEI,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Sufficient Evidence | IMEMDT 39,287,1986 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Sufficient Evidence | IMEMDT 71,865,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 39,287,1986 |
International Agency for Research on Cancer (IARC) Cancer Review | Human Inadequate Evidence | IMEMDT 71,865,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 2B | IMEMDT 71,865,1999 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - AUSTRIA | MAK 0.01 ppm (0.07 mg/m3), JAN1999 | |
Occupational Exposure Limit - DENMARK | time-weighted average 0.005 ppm (0.035 mg/m3), JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 0.01 ppm (0.07 mg/m3), JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 0.005 ppm (0.035 mg/m3), JAN1999 | |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 0.035 mg/m3, MAC(short term exposure limit) 0.070 mg/m3, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 0.005 ppm (0.04 mg/m3), KZG- week 0.01 ppm (0.8 mg/m3), JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, SEP2000 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 0.04 mg/m3, 2003 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: M0788; Number of Industries 14; Total Number of Facilities 609; Number of Occupations 18; Total Number of Employees Exposed 15,830 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: M0788![]() Number of Industries 12; Total Number of Facilities 415; Number of Occupations 22; Total Number of Employees Exposed 2,872; Total Number of Female Employees Exposed 284 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used in the production of POLYURETHANE flexible foams, coatings, and elastomers | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521 | |
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen | |
OSHA ANALYTICAL METHOD #42 |
REFERENCES: | |
CODEN |
REFERENCE |
AECTCV | Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- |
ATXKA8 | Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NTPTR* | National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- |