The Registry of Toxic Effects of Chemical Substances
Benzene, (dichloromethyl) - RTECS #: CZ5075000
CAS #: 98-87-3
The Registry of Toxic Effects of Chemical Substances
Benzene, (dichloromethyl) - |
| UPDATE: February 2003 | MW: 161.03 | MF: C7H6Cl2 |
SYNONYMS:
|
|
| |
SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
DNA repair
|
Bacillus subtilis
|
31 µmol/disc
|
MUREAV 58,143,1978
|
mutation in microorganisms
|
Escherichia coli
|
600 nmol/plate/20 minute (+enzymatic activation step)
|
MUREAV 58,143,1978
|
mutation in microorganisms
|
Salmonella typhimurium
|
600 nmol/plate/20 minute (-enzymatic activation step)
|
MUREAV 58,143,1978
|
| |||
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
skin | mouse
lowest published toxic dose: 9,200 mg/kg/50 week- intermittent
|
Tumorigenic: Carcinogenic by RTECS criteria | Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors
GANNA2 72,655,1981
|
skin | mouse
toxic dose : 35,200 mg/kg/42 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors
GANNA2 72,655,1981
|
| |||
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mammal (species unspecified)
lethal concentration (50 percent kill): 210 mg/m3
|
N/R
|
GTPZAB 30(3),6,1986
|
inhalation | mouse
lethal concentration (50 percent kill): 32 ppm/2 hour
|
Brain and Coverings: Recordings from specific areas of CNS | Behavioral: Excitement Lung, Thorax, or Respiration: Respiratory depression
IMEMDT 29,65,1982
|
inhalation | mouse
lethal concentration (50 percent kill): 210 mg/m3
|
Behavioral: General anesthetic | Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
|
inhalation | rat
lethal concentration (50 percent kill): 61 ppm/2 hour
|
Brain and Coverings: Recordings from specific areas of CNS | Behavioral: Excitement Lung, Thorax, or Respiration: Respiratory depression
IMEMDT 29,65,1982
|
inhalation | rat
lethal concentration (50 percent kill): 400 mg/m3
|
Behavioral: General anesthetic | Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
|
oral | mammal (species unspecified)
lethal dose (50 percent kill): 1,400 mg/kg
|
N/R
|
GISAAA 40(1),92,1975
|
oral | mouse
lethal dose (50 percent kill): 2,462 mg/kg
|
N/R
|
AMRL** TR-72-62,1972
|
oral | mouse
lethal dose (50 percent kill): 1,400 mg/kg
|
Behavioral: General anesthetic | Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
|
oral | rat
lethal dose (50 percent kill): 3,249 mg/kg
|
N/R
|
AMRL** TR-72-62,1972
|
oral | rat
lethal dose (50 percent kill): 1,400 mg/kg
|
Behavioral: General anesthetic | Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
|
| |||
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Limited Evidence
|
IMEMDT 29,65,1982
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Limited Evidence
|
IMEMDT 71,453,1999
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Limited Evidence
|
IMEMDT 71,453,1999
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Inadequate Evidence
|
IMEMDT 29,65,1982
|
| ||
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
Occupational Exposure Limit - AUSTRIA
|
Carcinogen, JAN1999
|
Occupational Exposure Limit - FINLAND
|
Carcinogen, JAN1993
|
Occupational Exposure Limit - GERMANY
|
Carcinogen, JAN1999
|
Occupational Exposure Limit - RUSSIA
|
short term exposure limit 0.5 mg/m3, JAN1993
|
Occupational Exposure Limit - SWEDEN
|
Carcinogen, JAN1999
|
| |||||||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
N/R
|
N/R
|
N/R
|
| ||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
|
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
|
FEREAC 47,26992,82
|
Used in the manufacture of BENZALDEHYDE and CINNAMIC ACID
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
| |||||
REFERENCES:
CODEN
|
|
REFERENCE
AMRL**
|
Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems
Command, Wright-Patterson Air Force Base, OH 45433)
|
FEREAC
|
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
|
GANNA2
|
Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher
information, see JJCREP.
|
GISAAA
|
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
|
GTPZAB
|
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
|
IMEMDT
|
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
VCVGK*
|
"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
|
| |