The Registry of Toxic Effects of Chemical Substances

1,2 - Benzenedicarboxylic acid, di - 2 - propenyl ester

RTECS #: CZ4200000

CAS #: 131-17-9

UPDATE: November 2004 MW: 246.28 MF: C14H14O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Dapon 35
  2. Dapon R
  3. Diallyl phthalate
  4. Diallylester kyseliny ftalove (Czech)
  1. Diallylphthalate
  2. NCI - C50657
  3. Phthalic acid, diallyl ester
  4. o - Phthalic acid, diallyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg mild AJOPAA 29,1363,1946
skin
rabbit 		500 mg moderate NTIS** OTS0521089


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 200 mg/L SCIEAS 236,933,1987
cytogenetic analysis intraperitoneal
mouse 		300 mg/kg EMMUEG 25,302,1995
mutation in microorganisms mouse lymphocyte 67,200 µg/L (+enzymatic activation step) SCIEAS 236,933,1987
mutation in mammalian somatic cells mouse lymphocyte 67,200 µg/L SCIEAS 236,933,1987
sister chromatid exchange hamster ovary 160 mg/L SCIEAS 236,933,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 156 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		EVHPAZ 65,271,1986
oral
mouse 		lowest published toxic dose: 154,500 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Blood: Lymphoma including Hodgkin's disease 		NTIS** PB83-200824
oral
mouse 		lowest published toxic dose: 154,500 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB83-200824
oral
rat 		lowest published toxic dose: 52 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		EVHPAZ 65,271,1986
oral
rat 		lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NTIS** PB86-203742/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 5,200 mg/m3/1 hour Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0521092
oral
dog 		lowest published lethal dose: 800 mg/kg N/R NTIS** OTS0521092
oral
mouse 		lowest published lethal dose: 681 mg/kg N/R NTPTR* NTP-TR-242,1983
oral
rat 		lethal dose (50 percent kill): 656 mg/kg Behavioral: Somnolence (general depressed activity) NTPTR* NTP-TR-284,1985
oral
rabbit 		lethal dose (50 percent kill): 1,700 mg/kg N/R 14CYAT 2,1904,1963
subcutaneous
rabbit 		lowest published lethal dose: 1 gm/kg Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse 		FEPRA7 5,191,1946
skin
rabbit 		lethal dose (50 percent kill): 3,300 mg/kg N/R NTIS** OTS0521092


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-242,1983
oral
rat 		lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-284,1985
oral
rat 		lowest published toxic dose: 26 gm/kg/13 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-284,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
RREVAH 54,1,1975
TOXICOLOGY REVIEW
EVHPAZ 4,3,1973
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 23180;
Number of Industries 15;
Total Number of Facilities 390;
Number of Occupations 27;
Total Number of Employees Exposed 8,596
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 23180;
Number of Industries 11;
Total Number of Facilities 484;
Number of Occupations 18;
Total Number of Employees Exposed 8,784;
Total Number of Female Employees Exposed 2,027


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as dye carrier and cross-linking agent in manufacture of unsaturated polyester resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat
NTP Carcinogenesis Studies (gavage);inadequate studies:mouse,rat NTPTR* NTP-TR-242,1983


REFERENCES:

CODEN
REFERENCE
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-

Used as dye carrier and cross-linking agent in manufacture of unsaturated polyester resins

NIOSH PROFILE (PHTHALATES), SRI, 2/77

NIOSH PROFILE (PHTHALATES), SRC, 3/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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