The Registry of Toxic Effects of Chemical Substances

Benzenamine, hydrochloride

RTECS #: CY0875000

CAS #: 142-04-1

UPDATE: August 2004 MW: 129.60 MF: C6H7N•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Aniline chloride
  2. Aniline hydrochloride (6CI,8CI)
  3. Anilinium chloride
  4. NCI - C03736 hydrochloride
  5. Chlorhydrate d'aniline (French)
  6. Chlorid anilinu (Czech)
  1. C.I. 76001
  2. Phenylamine hydrochloride
  3. Phenylammonium chloride
  4. Sul anilinova (Czech)
  5. USAF EK - 442


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,459,1986
skin
rabbit 		500 mg/24 hour moderate 28ZPAK -,65,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test intraperitoneal
mouse 		1 gm/kg CRNGDP 12,1057,1991
morphological transform rat embryo 79,500 ng/plate JJATDK 1,190,1981
sister chromatid exchange hamster fibroblast 10 µmol/L JNCIAM 58,1635,1977
sister chromatid exchange human lymphocyte 50 µmol/L BLFSBY 29B,561,1984
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		5 pph MUREAV 413,15,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,400 mg/kg (7-20 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) TXAPA9 77,465,1985
oral
rat 		lowest published toxic dose: 1,400 mg/kg (7-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) 		NTIS** OTS0555028
subcutaneous
rat 		lowest published toxic dose: 780 mg/kg (19-21 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TJADAB 52,14B,1995


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 130 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Blood: Tumors 		NCITR* NCI-TR-130,1978
oral
rat 		toxic dose : 238 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Blood: Tumors 		NCITR* NCI-TR-130,1978
oral
rat 		toxic dose : 137 gm/kg/60 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors 		IMEMDT 27,39,1982
oral
rat 		toxic dose : 2,163 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors 		IMEMDT 27,39,1982
oral
rat 		toxic dose : 4,326 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors 		IMEMDT 27,39,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 460 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia JPETAB 80,31,1944
oral
mouse 		lethal dose (50 percent kill): 841 mg/kg N/R NTIS** PB214-270
oral
rat 		lethal dose (50 percent kill): 840 mg/kg N/R TXAPA9 42,417,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 440 mg/kg/2 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		MOCAT* 18,283,2003
intraperitoneal
mouse 		lowest published toxic dose: 760 mg/kg/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field MOCAT* 18,283,2003
oral
rat 		lowest published toxic dose: 1,944 mg/kg/30 day- intermittent Endocrine: Changes in spleen weight

Blood: Changes in spleen 		TOXID9 42,150,1998
oral
rat 		lowest published toxic dose: 1,800 mg/kg/90 day- continuous Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count 		AECTCV 24,368,1993
oral
rat 		lowest published toxic dose: 910 mg/kg/7 day- intermittent Endocrine: Changes in spleen weight

Blood: Changes in spleen

Nutritional and Gross Metabolic: Changes in: Fe 		FAATDF 35,22,1997
oral
rat 		lowest published toxic dose: 907 mg/kg/7 day- intermittent Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 72,78,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 27,39,1982


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2301;
Number of Industries 3;
Total Number of Facilities 136;
Number of Occupations 2;
Total Number of Employees Exposed 260
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2301;
Number of Industries 58;
Total Number of Facilities 5,101;
Number of Occupations 38;
Total Number of Employees Exposed 82,371;
Total Number of Female Employees Exposed 47,136


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an industrial chemical and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:rat NCITR* NCI-TR-130,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* NCI-TR-130,1978


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MOCAT* Molecular Cancer Therapeutics (Philadelphia, PA : American Association for Cancer Research) V.1- 2001-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an industrial chemical and chemical intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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