The Registry of Toxic Effects of Chemical Substances

Barium chloride

RTECS #: CQ8750000

CAS #: 10361-37-2

UPDATE: November 2004 MW: 208.24 MF: BaCl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. NCI - C61074
  2. SBA 0108E
  1. Barium dichloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination Saccharomyes cerevisiae 14 mmol/L MUTAEX 1,21,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
rat 		lowest published toxic dose: 16,659 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 39 mg/kg N/R FATOBP 10,107,1975
intraperitoneal
mouse 		lethal dose (50 percent kill): 56.2 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVN1* -,136,1988
intravenous
cat 		lowest published lethal dose: 40 mg/kg N/R EQSSDX 1,1,1975
intravenous
mouse 		lethal dose (50 percent kill): 12 mg/kg N/R TXAPA9 22,150,1972
intravenous
rat 		lowest published lethal dose: 20 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Other changes 		JLCMAK 15,35,1929
intravenous
rabbit 		lowest published lethal dose: 15 mg/kg N/R EQSSDX 1,1,1975
intravenous
rabbit 		lowest published toxic dose: 4 mg/kg Cardiac: Arrythmias (indlucing changes in conduction) FATOAO 51,50,1988
oral
dog 		lowest published lethal dose: 90 mg/kg N/R 27ZIAQ -,53,1973
oral
guinea pig 		lethal dose (50 percent kill): 76 mg/kg N/R FOREAE 7,313,1942
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 398 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Muscle weakness

Gastrointestinal: Nausea or vomiting 		GTPZAB 28(6),45,1984
oral
mouse 		lowest published lethal dose: 70 mg/kg N/R EQSSDX 1,1,1975
oral
mouse 		lethal dose (50 percent kill): 150 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVN1* -,136,1988
oral
rat 		lethal dose (50 percent kill): 118 mg/kg N/R FOREAE 7,313,1942
oral
rat 		lethal dose (50 percent kill): 397 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVN1* -,136,1988
oral
rabbit 		lowest published lethal dose: 170 mg/kg N/R 27ZIAQ -,53,1973
parenteral
domestic animal 		lowest published lethal dose: 7 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle weakness 		NEZTAF 47,150,1999
parenteral
rat 		lowest published toxic dose: 35 µg/kg Cardiac: Arrythmias (indlucing changes in conduction) PCJOAU 37,6,2003
parenteral
rabbit 		lowest published lethal dose: 20 mg/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased 		MELAAD 30,44,1939
subcutaneous
cat 		lowest published lethal dose: 18 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
dog 		lowest published lethal dose: 10 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
frog 		lowest published lethal dose: 910 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
guinea pig 		lowest published lethal dose: 55 mg/kg N/R 27ZIAQ -,53,1973
subcutaneous
mouse 		lowest published lethal dose: 10 mg/kg N/R NTIS** AEC-TR-6710
subcutaneous
rat 		lethal dose (50 percent kill): 178 mg/kg N/R 27ZIAQ -,53,1973
subcutaneous
rabbit 		lowest published lethal dose: 40 mg/kg N/R EQSSDX 1,1,1975
unreported route
dog 		lethal dose (50 percent kill): 90 mg/kg N/R NEZTAF 47,150,1999
unreported route
human 		lowest published lethal dose: 114.3 mg/kg N/R VCVN1* -,138,1988
unreported route
horse, donkey 		lethal dose (50 percent kill): 800 mg/kg N/R NEZTAF 47,150,1999
unreported route
mouse 		lethal dose (50 percent kill): 7 mg/kg N/R NEZTAF 47,150,1999
unreported route
rat 		lethal dose (50 percent kill): 150 mg/kg N/R NEZTAF 47,150,1999
unreported route
rabbit 		lethal dose (50 percent kill): 170 mg/kg N/R NEZTAF 47,150,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 91 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		GISAAA 45(6),86,1980
oral
rat 		lowest published toxic dose: 3 gm/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in ovarian weight 		JACTDZ 7(5),675,1988
oral
rat 		lowest published toxic dose: 70 mg/kg/4 week- continuous Cardiac: Other changes

Vascular: BP elevation not characterized in autonomic section 		VCVN1* -,138,1988
oral
rat 		lowest published toxic dose: 84 mg/kg/24 week- intermittent Behavioral: Alteration of classical conditioning

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		VCVN1* -,138,1988
subcutaneous
rat 		lowest published toxic dose: 280 mg/kg/4 week- intermittent Liver: Other changes

Endocrine: Other changes

Blood: Changes in leukocyte (WBC) count 		VCVN1* -,138,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Ba)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
FOREAE 7,313,1942


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Ba)/m3 DTLVS* 3,21,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Ba)/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg(Ba)/m3, MAC(short term exposure limit) 1.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 4 mg(Ba)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as a human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as a human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 08650;
Number of Industries 46;
Total Number of Facilities 1,971;
Number of Occupations 30;
Total Number of Employees Exposed 13,339
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 08650;
Number of Industries 62;
Total Number of Facilities 4,299;
Number of Occupations 62;
Total Number of Employees Exposed 57,997;
Total Number of Female Employees Exposed 15,249


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964-
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEZTAF New Zealand Veterinary Journal. (New Zealand Veterinary Assoc., POB 524, Wellington, 1, New Zealand) V.1- 1952-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as a mordant, pesticide, water softener boiler compound, to tan and finish leather

NIOSH PROFILE (BARIUM and ITS COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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