The Registry of Toxic Effects of Chemical Substances

2H - Azepin - 2 - one, hexahydro -

RTECS #: CM3675000

CAS #: 105-60-2

UPDATE: November 2004 MW: 113.18 MF: C6H11NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,6 - Hexolactam
  2. 1 - Aza - 2 - cycloheptanone
  3. 2 - Azacycloheptanone
  4. 2 - Ketohexamethyleneimine
  5. 2 - Ketohexamethylenimine
  6. 2 - Oxohexamethyleneimine
  7. 2 - Oxohexamethylenimine
  8. 2 - Perhydroazepinone
  9. 2H - Azepin - 7 - one, hexahydro -
  10. 6 - Aminocaproic acid lactam
  11. 6 - Aminohexanoic acid cyclic lactam
  12. 6 - Caprolactam
  13. 6 - Hexanelactam
  14. A1030
  15. Aminocaproic lactam
  16. Caprolactam
  17. Caprolactam monomer
  18. Caprolactam, fume
  19. Caprolattame (French)
  1. Capron PK4
  2. Cyclohexanone iso - oxime
  3. Epsylon kaprolaktam (Polish)
  4. Extrom 6N
  5. Hexahydro - 2 - azepinone
  6. Hexahydro - 2H - azepin - 2 - one (9CI)
  7. Hexamethylenimine, 2 - oxo -
  8. Hexanoic acid, 6 - amino - , cyclic lactam
  9. Hexanoic acid, 6 - amino - , lactam
  10. Hexanolactam
  11. Hexanone isoxime
  12. Hexanonisoxim (German)
  13. Kapromine
  14. NCI - C50646
  15. Stilon
  16. e - Kaprolaktam (Czech)
  17. epsilon - Caprolactam
  18. epsilon - Caprolactam (ACGIH)
  19. omega - Caprolactam


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,883,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,883,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
ovary 		76 mg/kg MUREAV 143,263,1985
cytogenetic analysis hamster lung 8 gm/L PMRSDJ 5,427,1985
cytogenetic analysis human lymphocyte 270 mg/L PMRSDJ 5,457,1985
DNA damage intraperitoneal
mouse 		580 mg/kg MUREAV 224,379,1989
DNA damage intraperitoneal
rat 		580 mg/kg MUREAV 224,379,1989
DNA inhibition human fibroblast 1 mmol/L NEOLA4 33,699,1986
mutation in microorganisms Saccharomyes cerevisiae 100 mg/L (+/-enzymatic activation step) PMRSDJ 5,271,1985
micronucleus test multiple
non-mammalian species 		100 ppm MUTAEX 4,17,1989
gene conversion and mitotic recombination Saccharomyes cerevisiae 400 mg/L PMRSDJ 5,271,1985
morphological transform hamster embryo 100 mg/L TIVIEQ 2,103,1988
morphological transform mouse embryo 2,500 mg/L PMRSDJ 5,639,1985
phage inhibition capacity Escherichia coli 1,950 µg/well MUREAV 260,349,1991
sister chromatid exchange hamster ovary 125 mmol/L MUREAV 224,333,1989
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		5 mmol/L MUREAV 224,339,1989
sex chromosome loss and nondisjunction human lymphocyte 25 mmol/L MUREAV 224,333,1989
specific locus test oral
Drosophila melanogaster 		5 mmol/L PMRSDJ 5,313,1985
specific locus test intraperitoneal
mouse 		500 mg/kg MUREAV 224,369,1989
sperm morphology inhalation
rat 		125 mg/m3/10 week GTPZAB 19(10),40,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 125 mg/m3/24 hour (76 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) GTPZAB 19(10),40,1975
inhalation
rat 		lowest published toxic dose: 473 mg/m3/4 hour (1-5 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death 		GISAAA 34(7),25,1969
inhalation
rat 		lowest published toxic dose: 139 mg/m3/4 hour (6-12 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) GISAAA 34(7),25,1969
inhalation
rat 		lowest published toxic concentration: 473 mg/m3/4 hour (60 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders GTPZAB 13(10),22,1969
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JJATDK 7,317,1987
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** OTS0537802
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		NTIS** OTS0557708
oral
rabbit 		lowest published toxic dose: 3,450 mg/kg (6-28 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JJATDK 7,317,1987
oral
rabbit 		lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** OTS0537802


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 100 ppm Lung, Thorax, or Respiration: Cough AIHAAP 34,384,1973
inhalation
mouse 		lethal concentration (50 percent kill): 450 mg/m3 Behavioral: Muscle contraction or spasticity GTPZAB 10(10),54,1966
inhalation
rat 		lethal concentration (50 percent kill): 300 mg/m3/2 hour N/R 85GMAT -,32,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 650 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Antipsychotic

Behavioral: Analgesia 		JPMSAE 60,1058,1971
intraperitoneal
rat 		lowest published lethal dose: 800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Body temperature decrease 		BJIMAG 11,1,1954
intravenous
mouse 		lethal dose (50 percent kill): 480 mg/kg N/R IMEMDT 39,247,1986
intravenous
rabbit 		lethal dose : >300 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Body temperature decrease 		BJIMAG 11,1,1954
oral
mouse 		lethal dose (50 percent kill): 930 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GTPZAB 10(10),54,1966
oral
rat 		lethal dose (50 percent kill): 1,210 mg/kg Eye: Chromodacryorrhea

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease 		NTPTR* NTP-TR-214,1982
subcutaneous
frog 		lowest published lethal dose: 2,800 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		AEXPBL 50,199,1903
subcutaneous
guinea pig 		lowest published lethal dose: 950 mg/kg N/R MELAAD 43,124,1952
subcutaneous
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R IMEMDT 39,247,1986
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R NTIS** OTS0557720
skin
rabbit 		lethal dose (50 percent kill): 1,410 µL/kg N/R AIHAAP 30,470,1969
unreported route
mouse 		lethal dose (50 percent kill): 930 mg/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		GISAAA 55(10),33,1990
unreported route
rat 		lethal dose (50 percent kill): 580 mg/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		GISAAA 55(10),33,1990
unreported route
rabbit 		lethal dose (50 percent kill): 1 gm/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased 		GISAAA 55(10),33,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 243 mg/m3/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		TOSCF2 44,197,1998
inhalation
rat 		lowest published toxic concentration: 5,960 mg/kg/82 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 33(1),22,1968
intraperitoneal
rat 		lowest published toxic dose: 9,100 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in other cell count (unspecified)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		MEPAAX 18,357,1967
oral
rat 		lowest published toxic dose: 42 gm/kg/8 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain ARZNAD 9,9,1959
oral
rat 		lowest published toxic dose: 6,750 mg/kg/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0555505


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Suspected as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 10 ppm (vapor) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 3 mg/m3 (particulate) DTLVS* TLV/BEI,2002
International Agency for Research on Cancer (IARC) Cancer Review Animal NO EVIDENCE IMEMDT 39,247,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal No Evidence IMEMDT 71,383,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,247,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,383,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 4 IMEMDT 71,383,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (dust), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (vapor), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 mg/m3 (dust), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (dust), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 4.3 ppm (20 mg/m3), short term exposure limit 8.6 ppm (40 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3 (dudt), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (dust), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3 (fume), 2003
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3 (dust), 2003
Occupational Exposure Limit - FRANCE VME 1 mg/m3 (dust), JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (20 mg/m3) (vapor), JAN1993
Occupational Exposure Limit - GERMANY MAK 25 mg/m3 (dust and vapor), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3 (dust), JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (25 mg/m3), moist, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3 (dust), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3 (dust), JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3 (dust), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, dust, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (23 mg/m3), short term exposure limit 10 ppm, vapor, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 3 mg/m3 (particulate)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 3 mg/m3 (particulate)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPROLACTAM, dust-air 10 hour time-weighted average 1 mg/m3;
short term exposure limit 3 mg/m3 		NIOSH* DHHS #95-121,1995
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAPROLACTAM, vapor-air 10 hour time-weighted average 0.22 ppm;
short term exposure limit 0.66 ppm 		NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83732;
Number of Industries 14;
Total Number of Facilities 955;
Number of Occupations 14;
Total Number of Employees Exposed 6,208
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83732;
Number of Industries 12;
Total Number of Facilities 812;
Number of Occupations 19;
Total Number of Employees Exposed 25,091;
Total Number of Female Employees Exposed 8,291


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of NYLON 66, resins and films and as solvent and additive
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used in production of NYLON 66, resins and films and as solvent and additive

Top 50 chemical production: 1.38 billions lbs in 1992, 1.28 billions in 1991

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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