The Registry of Toxic Effects of Chemical Substances

Aspartic acid, L -

RTECS #: CI9098500

CAS #: 56-84-8

UPDATE: August 2003 MW: 133.12 MF: C4H7NO4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. (S) - Aminobutanedioic acid
  2. L - Aminosuccinic acid
  3. Asparagic acid
  4. L - Asparagic acid
  5. Asparaginic acid
  6. Aspartic acid
  7. (L) - Aspartic acid
  1. L - Asparaginic acid
  2. ASPARAGINSAEURE (German)
  3. (+) - Aspartic acid
  4. Butanedioic acid, amino - , (S) -
  5. H - Asp - OH
  6. L - (+) - Aspartic acid
  7. (S) - Aspartic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange human lymphocyte 10 mg/L MUREAV 372,75,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 6 gm/kg N/R PCJOAU 25,569,1991
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg Behavioral: Change in motor activity (specific assay) FATOAO 53,22,1990
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Behavioral: Alteration of classical conditioning FATOAO 53,22,1990
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Alteration of operant conditioning FATOAO 53,22,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg/10 day- intermittent Behavioral: Alteration of classical conditioning FATOAO 53,22,1990
intraperitoneal
rat 		lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Behavioral: Excitement

Behavioral: Alteration of classical conditioning 		FATOAO 53,22,1990
oral
rat 		lowest published toxic dose: 25,079 mg/kg/7 day- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		ARZNAD 32,738,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81861;
Number of Industries 3;
Total Number of Facilities 803;
Number of Occupations 3;
Total Number of Employees Exposed 5,939
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81861;
Number of Industries 3;
Total Number of Facilities 634;
Number of Occupations 11;
Total Number of Employees Exposed 9,033;
Total Number of Female Employees Exposed 6,545


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-

RTECS Compound Description:
   Drug
   Mutagen
   Natural Product

ALT CAS #: 6899-03-2
ALT CAS #: 181119-33-5
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