The Registry of Toxic Effects of Chemical Substances

Asbestos

RTECS #: CI6475000

CAS #: 1332-21-4

UPDATE: May 2005 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Amianthus
  2. Amosite (Obs.)
  3. Amphibole
  4. Asbest (German)
  5. Asbestos (ACGIH:OSHA)
  1. Asbestos fiber
  2. Asbestos fibre
  3. Asbestos, all forms
  4. Fibrous grunerite
  5. NCI C08991


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 10 mg/plate (+/-enzymatic activation step) PSEBAA 177,343,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 750 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		ZEKBAI 62,561,1958
intraperitoneal
mouse 		lowest published toxic dose: 80 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		PAACA3 24,61,1983


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 1.2 fiber/cubic centimeter/19 year- continuous Lung, Thorax, or Respiration: Pleural effusion

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Sputum 		ARDSBL 104,576,1971
intratracheal
rat 		lethal dose : >4 mL/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		CHYCDW 32,139,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 f/cubic centimeter (F) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 2,17,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 2,17,1973
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 14,11,1977
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 14,11,1977
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,106,1987
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
JJOMDZ 15,808,1973
TOXICOLOGY REVIEW
CANCAR 39,1792,1977
TOXICOLOGY REVIEW
85CVA2 5,55,1970
TOXICOLOGY REVIEW
31BYAP -,92,1974
TOXICOLOGY REVIEW
ZHPMAT 166,113,1978
TOXICOLOGY REVIEW
NOSYBW 40,311,1977
TOXICOLOGY REVIEW
PEXTAR 12,102,1969
TOXICOLOGY REVIEW
NTIS** CONF-691001
TOXICOLOGY REVIEW
CNDIBJ 85,559,1976
TOXICOLOGY REVIEW
TOLED5 127,251,2002
TOXICOLOGY REVIEW
TOLED5 140-141,223,2003
TOXICOLOGY REVIEW
TOLED5 140-141,311,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 fiber/cubic centimeter (fiber > 5 um) DTLWS* 3,33,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.58 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 f/cubic centimeter CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) CANCER AND LUNG DISEASE HAZARD CFRGBR 29,1910.1001,1991
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.3 fiber/ml, continuous1 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 fiber/cm3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.25 fiber/ml, Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ASBESTOS-air 100 minute time-weighted average 0.1 fiber/cubic centimeter in a 400L air sample NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 90310;
Number of Industries 154;
Total Number of Facilities 30,863;
Number of Occupations 117;
Total Number of Employees Exposed 449,904
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 90310;
Number of Industries 81;
Total Number of Facilities 15,617;
Number of Occupations 86;
Total Number of Employees Exposed 215,265;
Total Number of Female Employees Exposed 9,727


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109101)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of ASBESTOS cement sheets and pipes, insulation materials, floor tiles
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 5, 1975
NIOSH Analytical Method, 1994: Asbestos (bulk) by PLM, 9002; by PCM, 7400; by TEM, 7402
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays, International Symposium, 1974," Karbe, E., and J.F. Park, eds., Springer-Verlag New York, Inc., 1974
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CNDIBJ Cahiers de Notes Documentaires. (Institut National de Recherche et de Securite, 30 rue Olivier Noyer, 75680 Paris Cedex, 14, France) No.1- 1955-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NOSYBW Nobel Symposium. (Nobel Foundation, Sturegatan 14, S-11436 Stockholm, Sweden) No.1- 1966-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7.
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.

Used in manufacture of ASBESTOS cement sheets and pipes, insulation materials, floor tiles

NIOSH PROFILE (DEMOLITION and WRECKING), SRC, 1/80

NIOSH PROFILE (DENTISTRY), SRC, 2/80

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Natural Product

 Click Here for Additional Information about RTECS