The Registry of Toxic Effects of Chemical Substances
Arsenic acid, calcium salt (2:3) |
| UPDATE: November 2004 | MW: 398.08 | MF: As2O8•3Ca |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
| SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
| N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
|
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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intratracheal hamster | lowest published toxic dose: 120 mg/kg/15 week- continuous |
Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | CALEDQ 27,99,1985 |
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intratracheal hamster | toxic dose : 214 mg/kg/15 week- intermittent |
Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | IJCNAW 40,220,1987 |
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intratracheal rat | lowest published toxic dose: 1,600 µg/kg |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Tumorigenic: Tumors at site of application | IJCNAW 24,786,1979 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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oral dog | lethal dose (50 percent kill): 38 mg/kg | N/R | 85DPAN -,-,1971/1976 |
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oral mouse | lethal dose (50 percent kill): 794 mg/kg | N/R | AMRL** TR-72-62,1972 |
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oral rat | lethal dose (50 percent kill): 20 mg/kg |
Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Dehydration | AFDOAQ 15,122,1951 |
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oral rabbit | lowest published lethal dose: 50 mg/kg | N/R | JPETAB 39,246,1930 |
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skin rat | lethal dose (50 percent kill): 2,400 mg/kg | N/R | 28ZEAL 5,35,1976 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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oral rat | lowest published toxic dose: 24 gm/kg/2 year- continuous |
Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | PHRPA6 56,1610,1941 |
REVIEWS: | ||
| ORGANIZATION | STANDARD |
REFERENCE |
| American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.01 mg(As)/m3 | DTLVS* TLV/BEI,1997 |
| American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Confirmed human carcinogen | DTLVS* TLV/BEI,1999 |
| International Agency for Research on Cancer (IARC) Cancer Review | Human Sufficient Evidence | IMEMDT 23,39,1980 |
| International Agency for Research on Cancer (IARC) Cancer Review | Animal Limited Evidence | IMSUDL 7,100,1987 |
| International Agency for Research on Cancer (IARC) Cancer Review | Animal Inadequate Evidence | IMEMDT 23,39,1980 |
| International Agency for Research on Cancer (IARC) Cancer Review | Group 1 | IMSUDL 7,100,1987 |
| TOXICOLOGY REVIEW |
| 85DHAX As,-,1977 |
| TOXICOLOGY REVIEW |
| TOLED5 133,1,2002 |
STANDARDS AND REGULATIONS: | ||
| ORGANIZATION | STANDARD |
REFERENCE |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 | PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF | PESTICIDES: Cancelled | RBREV* -,160,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 0.5 mg(As)/m3 | DTLVS* 3,16,1971 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 1 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) | cancer hazard | CFRGBR 29,1910.1018,1987 |
| Occupational Exposure Limit - AUSTRIA | Carcinogen, JAN1999 | |
| Occupational Exposure Limit - DENMARK | time-weighted average 1 mg(As)/m3, JAN1999 | |
| Occupational Exposure Limit - GERMANY | Carcinogen, JAN1999 | |
| Occupational Exposure Limit - NORWAY | time-weighted average 0.01 mg(As)/m3, JAN1999 | |
| Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 1 mg/m3, JAN1993 | |
| Occupational Exposure Limit - POLAND | time-weighted average 0.01 mg(As)/m3, JAN1999 | |
| Occupational Exposure Limit - SWEDEN | time-weighted average 0.03 mg(As)/m3, Carcinogen, JAN1999 | |
| Occupational Exposure Limit - SWITZERLAND | MAK- week 0.1 mg(As)/m3, Carcinogen, JAN1999 | |
| Occupational Exposure Limit - TURKEY | time-weighted average 1 mg/m3, JAN1993 | |
| Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 0.1 mg(As)/m3, Carcinogen, SEP2000 | |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; Confirmed human carcinogen | |
| Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen |
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NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
| ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air | Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute | NIOSH* DHHS #92-100,1992 |
STATUS IN FEDERAL AGENCIES: | |
| ORGANIZATION |
REFERENCE |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| Used as an insecticide, pesticide and herbicide | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976 | |
| NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen | |
REFERENCES: | |
| CODEN |
REFERENCE |
| 28ZEAL | "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 |
| 85DHAX | "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 |
| 85DPAN | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 |
| AFDOAQ | Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74. |
| AMRL** | Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433) |
| CALEDQ | Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- |
| CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
| DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
| FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
| IJCNAW | International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- |
| IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
| IMSUDL | IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- |
| JPETAB | Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- |
| NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
| PHRPA6 | Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- |
| RBREV* | Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 |
| TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |