The Registry of Toxic Effects of Chemical Substances

Arsenic

RTECS #: CG0525000

CAS #: 7440-38-2

UPDATE: May 2005 MW: 74.92 MF: As


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Arsen (German,Polish)
  2. Arsenic (ACGIH:OSHA)
  3. Arsenic Black
  4. Arsenic, elemental
  5. Arsenic - 75
  1. Arsenicals
  2. Colloidal arsenic
  3. Grey arsenic
  4. Inorganic arsenic
  5. Metallic arsenic


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis unreported route
human 		4,286 µg/kg HUGEDQ 48,1,1979
cytogenetic analysis oral
human 		0.211 mg/L/15 year MUREAV 534,133,2003
cytogenetic analysis oral
mouse 		280 mg/kg/8 week MUREAV 113,293,1983
DNA damage human lung 5 µmol/L TOXID9 72,219,2003
sister chromatid exchange oral
human 		0.211 mg/L/15 year MUREAV 534,133,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 187 mg/kg (8-18 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system TOXID9 72,214,2003
oral
rat 		lowest published toxic dose: 605 µg/kg (35 week prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		GISAAA 42(8),30,1977
oral
rat 		lowest published toxic dose: 580 µg/kg (30 week prior to copulation/1-20 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FATOAO 41,620,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rabbit 		lowest published toxic dose: 75 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		ZEKBAI 52,425,1942
oral
man 		lowest published toxic dose: 76 mg/kg/12 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Hemorrhage 		RMCHAW 99,664,1971


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published lethal dose: 10 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes 		CRSBAW 81,164,1918
intraperitoneal
mouse 		lethal dose (50 percent kill): 46,200 µg/kg Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		GTPZAB 31(12),53,1987
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,000 mg/kg N/R VCVN5* -,87,1993
intraperitoneal
rat 		lethal dose (50 percent kill): 13,390 µg/kg N/R TXCYAC 64,191,1990
oral
child 		lowest published toxic dose: 4 mg/kg Cardiac: EKG changes not diagnostic of above

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		PECAE5 13,394,1997
oral
man 		lowest published toxic dose: 7,857 mg/kg/55 year Gastrointestinal: Changes in structure or function of esophagus

Blood: Hemorrhage

Skin: After systemic exposure: Dermatitis, other 		CMAJAX 120,168,1979
oral
mouse 		lethal dose (50 percent kill): 145 mg/kg Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		GTPZAB 31(12),53,1987
oral
mouse 		lethal dose (50 percent kill): 144 mg/kg N/R VCVN5* -,87,1993
oral
rat 		lethal dose (50 percent kill): 763 mg/kg Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		GTPZAB 31(12),53,1987
oral
rat 		lethal dose (50 percent kill): 763 mg/kg N/R VCVN5* -,87,1993
subcutaneous
guinea pig 		lowest published lethal dose: 300 mg/kg N/R ASBIAL 24,442,1938
subcutaneous
rabbit 		lowest published lethal dose: 300 mg/kg N/R ASBIAL 24,442,1938


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 280 mg/kg/4 week- continuous Immunological Including Allergic: Uncharacterized (multiple organ involvement) TOXID9 72,376,2003
oral
rat 		lowest published toxic dose: 1,360 mg/kg/17 day- intermittent Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Interstitial nephritis

Blood: Changes in cell count (unspecified) 		GTPZAB 31(12),53,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMSUDL 7,100,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 2,48,1973
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,100,1987
TOXICOLOGY REVIEW
EVHPAZ 110,883,2002
TOXICOLOGY REVIEW
EVHPAZ 110,767,2002
TOXICOLOGY REVIEW
JAVMA4 164,277,1974
TOXICOLOGY REVIEW
CTOXAO 5,151,1972
TOXICOLOGY REVIEW
ARPTDI 16,95,1976
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
PTPAD4 1,189,1976
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
85CVA2 5,63,1970
TOXICOLOGY REVIEW
PEXTAR 12,102,1969
TOXICOLOGY REVIEW
JOCMA7 2,137,1960
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
AMTODM 3,209,1977
TOXICOLOGY REVIEW
EVHPAZ 19,179,1977
TOXICOLOGY REVIEW
TOLED5 127,63,2002
TOXICOLOGY REVIEW
TOLED5 134,39,2002
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
85CVA2 5,250,1970
TOXICOLOGY REVIEW
TOLED5 128,69,2002
TOXICOLOGY REVIEW
CREOH* 42,93,2002
TOXICOLOGY REVIEW
TOLED5 145,1,2003
TOXICOLOGY REVIEW
MUREAV 567,109,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, JAN1993
Occupational Exposure Limit - HUNGARY short term exposure limit 0.5 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.02 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.03 mg/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 0.1 mg/m3, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 07545;
Number of Industries 8;
Total Number of Facilities 328;
Number of Occupations 18;
Total Number of Employees Exposed 5,929
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 07545;
Number of Industries 19;
Total Number of Facilities 1,100;
Number of Occupations 29;
Total Number of Employees Exposed 27,275;
Total Number of Female Employees Exposed 2,128


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108021)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an alloy additive, in electronic devices, and in veterinary medicines
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NIOSH Analytical Method, 1994: Arsenic and compounds, as As except AsH3/As2O3, 7900
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-105


REFERENCES:

CODEN
REFERENCE
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ASBIAL Archivio di Science Biologiche (Bologna). (Bologna, Italy) V.1-62, 1919-78. Discontinued.
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.31- 1976-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67. For publisher information, see:JJOMDZ
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1985-
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher information, see PHTHDT.
RMCHAW Revista Medica de Chile. (Sociedad Medica de Santiago, Esmeralda 678, Casilla 23-d, Santiago, Chile) V.1- 1872-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7.

Used as an alloy additive, in electronic devices, and in veterinary medicines

NIOSH PROFILE (GLASS and CERAMICS MANUFACTURE), SRC, 6/80

NIOSH PROFILE (SMELTERS, SECONDARY NON-FERROUS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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