The Registry of Toxic Effects of Chemical Substances

Arsenious acid, potassium salt

RTECS #: CG3800000

CAS #: 10124-50-2

UPDATE: May 2004 MW: 399.65 MF: AsH3O3•xK


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Kaliumarsenit (German)
  2. Potassium metaarsenite
  3. Arsenenous acid, potassium salt
  1. Arsenite de potassium (French)
  2. Arsonic acid, potassium salt
  3. NSC 3060


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human leukocyte 1 µmol/L/48 hour CNREA8 25,980,1965


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
child 		toxic dose : 390 mg/kg/3 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		AIMEAS 61,296,1964
oral
man 		lowest published toxic dose: 214 mg/kg/15 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors 		GASTAB 68,1582,1975
oral
man 		toxic dose : 7,560 mg/kg/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Tumors 		ANSUA5 99,348,1934
oral
man 		toxic dose : 441 mg/kg/3 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		ANSUA5 99,348,1934
skin
mouse 		lowest published toxic dose: 576 mg/kg/12 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		BMJOAE 2,1107,1922


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published lethal dose: 2 mg/kg N/R HBAMAK 4,1307,1935
intravenous
rabbit 		lowest published lethal dose: 6 mg/kg N/R HBAMAK 4,1307,1935
oral
dog 		lowest published lethal dose: 3 mg/kg N/R HBAMAK 4,1307,1935
oral
human 		lowest published toxic dose: 74 mg/kg Liver: Other changes

Skin: After systemic exposure: Dermatitis, other 		LANCAO 1,269,1953
oral
rat 		lethal dose (50 percent kill): 14 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Dehydration 		AFDOAQ 15,122,1951
subcutaneous
cat 		lowest published lethal dose: 5 mg/kg N/R HBAMAK 4,1307,1935
subcutaneous
dog 		lowest published lethal dose: 700 µg/kg N/R HBAMAK 4,1307,1935
subcutaneous
guinea pig 		lowest published lethal dose: 9 mg/kg N/R HBAMAK 4,1307,1935
subcutaneous
mouse 		lowest published lethal dose: 16 mg/kg N/R HBAMAK 4,1307,1935
subcutaneous
pigeon 		lowest published lethal dose: 12 mg/kg N/R FDWU** -,-,1931
subcutaneous
rabbit 		lowest published lethal dose: 8 mg/kg N/R HBAMAK 4,1307,1935
skin
rat 		lethal dose (50 percent kill): 150 mg/kg N/R PHJOAV 185,361,1960


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 2,48,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,39,1980
TOXICOLOGY REVIEW
85DHAX As,-,1977
TOXICOLOGY REVIEW
ENVRAL 16,139,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg(As)/m3, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - HUNGARY short term exposure limit 0.5 mg(As)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.03 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 mg(As)/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
ANSUA5 Annals of Surgery. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1885-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931
GASTAB Gastroenterology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1943-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933-

Used in veterinary medicine, and for chronic dermatitis in man

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data

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