The Registry of Toxic Effects of Chemical Substances

Arsenic chloride

RTECS #: CG1750000

CAS #: 7784-34-1

UPDATE: May 2005 MW: 181.27 MF: AsCl3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Arsenic butter
  2. Arsenous chloride
  3. Arsenous trichloride (9CI)
  4. Butter of arsenic
  5. Chlorure arsenieux (French)
  1. Chlorure d'arsenic (French)
  2. Fuming liquid arsenic
  3. Trichloroarsine
  4. Arsenic (III) chloride
  5. Trichlorure d'arsenic (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human leukocyte 600 nmol/L MUREAV 88,73,1981
DNA repair Bacillus subtilis 50 mmol/L MUREAV 31,185,1975
micronucleus test intraperitoneal
mouse 		5,500 µg/kg MUREAV 389,3,1997
morphological transform hamster embryo 3 µmol/L CNREA8 39,193,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 200 mg/m3/20 minute N/R HBTXAC 1,324,1955
inhalation
mouse 		lowest published lethal concentration: 338 ppm/10 minute N/R HBTXAC 1,324,1955
oral
rat 		lethal dose (50 percent kill): 48 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea 		GTPZAB 27(4),54,1983
oral
rat 		lethal dose (50 percent kill): 48 mg/kg N/R VCVN5* -,88,1993
oral
rat 		lowest published toxic dose: 330 mg/kg Behavioral: Alteration of classical conditioning

Gastrointestinal: Hypermotility, diarrhea

Liver: Other changes 		VCVN5* -,90,1993
skin
rat 		lethal dose (50 percent kill): 80 mg/kg N/R VCVN5* -,88,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,1997
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg(As)/m3, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - HUNGARY short term exposure limit 0.5 mg(As)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.03 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(As)/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82192;
Number of Industries 1;
Total Number of Facilities 139;
Number of Occupations 3;
Total Number of Employees Exposed 823
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82192;
Number of Industries 3;
Total Number of Facilities 36;
Number of Occupations 3;
Total Number of Employees Exposed 1,142;
Total Number of Female Employees Exposed 152


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the ceramic industry and in the synthesis of chlorine-containing arsenicals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in the ceramic industry and in the synthesis of chlorine-containing arsenicals

RTECS Compound Description:
   Mutagen

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