The Registry of Toxic Effects of Chemical Substances

Antimony oxide

RTECS #: CC5650000

CAS #: 1309-64-4

UPDATE: November 2004 MW: 291.50 MF: O3Sb2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. A 1582
  2. A 1588LP
  3. AP 50
  4. AT 3
  5. AT 3 (fireproofing agent)
  6. Amspec - KR
  7. Antimonious oxide
  8. Antimony White
  9. Antimony sesquioxide
  10. Antimony trioxide
  11. Antimony trioxide production
  12. Antimony trioxide production (ACGIH)
  13. Antimony (3+) oxide
  14. Antox
  15. Atox F
  16. Atox S
  17. C.I. 77052
  18. C.I. Pigment White 11
  19. Chemetron fire shield
  20. Dechlorane A - O
  21. Diantimony trioxide
  1. Exitelite
  2. Fireshield FSPO 405
  3. Flowers of antimony
  4. NCI - C55152
  5. Nyacol A 1510LP
  6. Nyacol A 1530
  7. Patox C
  8. Patox H
  9. Patox L
  10. Patox M
  11. Patox S
  12. Stibiox MS
  13. Thermoguard B
  14. Thermoguard L
  15. Thermoguard S
  16. Timonox
  17. Timonox White Star
  18. Twinkling star
  19. Weisspiessglanz (German)
  20. White star


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild NTIS** OTS0555447


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 50 mg/L MUREAV 415,109,1998
DNA damage inhalation
human 		0.12 ng/L/1 year EMMUEG 40,184,2002
DNA repair Bacillus subtilis 50 mmol/L MUREAV 77,109,1980
sister chromatid exchange hamster lung 90 µg/L MUREAV 264,163,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 270 µg/m3 (1-21 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		GISAAA 52(10),85,1987
inhalation
rat 		lowest published toxic concentration: 82 µg/m3 (1-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		GISAAA 52(10),85,1987
inhalation
rat 		lowest published toxic concentration: 270 µg/m3/24 hour (1-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		GISAAA 54(4),68,1989
intratesticular
rat 		lowest published toxic dose: 23,320 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 4,200 µg/m3/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		AIHAM* 20,1,1980
inhalation
rat 		toxic concentration (other than lowest) : 4 mg/m3/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		PESTC* 8,16,1980
inhalation
rat 		toxic concentration (other than lowest) : 1,600 µg/m3/52 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		AIHAM* 20,1,1980
inhalation
rat 		toxic concentration (other than lowest) : 50 mg/m3/7 hour/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JTEHD6 18,607,1986


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 172 mg/kg N/R 85GMAT -,23,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 3,250 mg/kg N/R EQSSDX 1,1,1975
intravenous
dog 		lowest published lethal dose: 3 mg/kg N/R HBAMAK 4,1289,1935
oral
rat 		lethal dose (50 percent kill): >34,600 mg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		NTIS** OTS0555447
subcutaneous
mammal (species unspecified) 		lethal dose : >120 mg/kg N/R GTPZAB 8(7),25,1964
subcutaneous
rat 		lethal dose (50 percent kill): 7,904 mg/kg N/R GISAAA 38(1),99,1973
subcutaneous
rabbit 		lowest published lethal dose: 2,500 µg/kg N/R HBAMAK 4,1289,1935
skin
rabbit 		lowest published lethal dose: 2 gm/kg N/R NTIS** OTS0555447


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 45 mg/m3/10 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 27,256,1945
inhalation
rat 		lowest published toxic concentration: 72 µg/m3/24 hour/17 week- continuous Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Lipids including transport 		GISAAA 54(4),68,1989
inhalation
rat 		lowest published toxic concentration: 4,500 µg/m3/6 hour/1 year- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0526425
oral
rat 		lowest published toxic dose: 152 gm/kg/90 day- continuous Liver: Changes in liver weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		JJATDK 19,205,1999
subcutaneous
rat 		lowest published toxic dose: 25,688 mg/kg/13 week- intermittent Cardiac: Other changes GISAAA 38(1),99,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average L DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 47,291,1989
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 47,291,1989
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 47,291,1989


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA short term exposure limit 0.5 ppm, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 0.5 ppm, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Sb)/m3, 2003
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Sb)/m3, 2B Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 0.2 mg(Sb)/m3, short term exposure limit 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 0.1 mg/m3, Carcinogen JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Sb)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Sb)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTIMONY-air 10 hour time-weighted average 0.5 mg(Sb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2263;
Number of Industries 31;
Total Number of Facilities 1,540;
Number of Occupations 53;
Total Number of Employees Exposed 28,957
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2263;
Number of Industries 72;
Total Number of Facilities 7,476;
Number of Occupations 76;
Total Number of Employees Exposed 209,773;
Total Number of Female Employees Exposed 56,911


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical, dye, pigment and printing ink
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAM* Annual Meeting of American Industrial Hygiene Association. (Akron, OH) For publisher information, see AIHAAP.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972-

Used as an industrial chemical, dye, pigment and printing ink

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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