The Registry of Toxic Effects of Chemical Substances

Anthraquinone, 2 - amino -

RTECS #: CB5120000

CAS #: 117-79-3

UPDATE: May 2005 MW: 223.24 MF: C14H9NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Amino - 9,10 - anthracenedione
  2. Aminoanthraquinone
  3. beta - Aminoanthraquinone
  4. 2 - Aminoanthraquinone
  5. 2 - Amino - 9,10 - anthraquinone
  1. 9,10 - Anthracenedione, 2 - amino - (9CI)
  2. AAQ
  3. NCI - C01876
  4. beta - Anthraquinonylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 1 mg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
micronucleus test mouse other cell types 6 mg/L EMMUEG 24,96,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 655 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease 		NCITR* NCI-TR-144,1978
oral
mouse 		toxic dose : 330 gm/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease 		NCITR* NCI-TR-144,1978
oral
mouse 		toxic dose : 2,730 gm/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		IMEMDT 27,191,1982
oral
mouse 		toxic dose : 5,600 gm/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		IMEMDT 27,191,1982
oral
rat 		lowest published toxic dose: 115 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-144,1978
oral
rat 		toxic dose : 225 gm/kg/78 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-144,1978
oral
rat 		toxic dose : 32 gm/kg/77 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		TOLED5 4,71,1979
oral
rat 		toxic dose : 1,890 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		IMEMDT 27,191,1982
oral
rat 		toxic dose : 3,780 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		IMEMDT 27,191,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 1,500 mg/kg N/R GTPZAB 21(12),27,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 336 gm/kg/8 week- continuous Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria 		MDBYAS 58,337,1980
oral
rat 		lowest published toxic dose: 77 gm/kg/48 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Hyperglycemia

Blood: Pigmented or nucleated red blood cells 		TXAPA9 25,453,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 27,191,1982
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,191,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye intermediate
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-144,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MDBYAS Medical Biology. (Finnish Medical Soc. Duodecim, Runeberginkatu 47 A, SF-00260 Helsinki 26, Finland) V.52- 1974-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a dye intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen

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