The Registry of Toxic Effects of Chemical Substances

Anisole, 2,4 - diamino -

RTECS #: BZ8580500

CAS #: 615-05-4

UPDATE: February 2003 MW: 138.19 MF: C7H10N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzenediamine, 4 - methoxy - (9CI)
  2. C.I. 76050
  3. C.I. Oxidation Base 12
  4. 2,4 - Diamineanisole
  5. 2,4 - Diaminoanisole
  6. 2,4 - Diaminoanisole base
  7. m - Diaminoanisole 1,3 - diamino - 4 - methoxybenzene
  8. 2,4 - Diamino - 1 - methoxybenzene
  1. Furro L
  2. 4 - Methoxy - 1,3 - benzenediamine
  3. p - Methoxy - m - phenylenediamine
  4. 4 - Methoxy - m - phenylenediamine
  5. Pelagol DA
  6. Pelagol Grey L
  7. Pelagol L
  8. m - Phenylenediamine, 4 - methoxy - (8CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		12,500 µg/24 hour mild FCTXAV 15,607,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct rat liver 500 µmol/L CBINA8 31,35,1980
DNA damage human fibroblast 50 µmol/L MUREAV 127,107,1984
DNA damage intraperitoneal
rat 		660 µmol/kg CRNGDP 2,1317,1981
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) CRNGDP 7,899,1986
mutation in microorganisms Salmonella typhimurium 1 nmol/plate/20 minute EMMUEG 38,268,2001
mutation in mammalian somatic cells mouse lymphocyte 18,750 gm/L JEPTDQ 1(1),87,1977
sister chromatid exchange intraperitoneal
mouse 		12 mg/kg MUREAV 108,225,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mammal (species unspecified) 		lowest published toxic dose: 65,100 µg/kg (10 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JIDOAA 35,387,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 116 mg/kg Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition 		BCPCA6 30,2715,1981
oral
rat 		lethal dose (50 percent kill): 460 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair 		FCTXAV 15,607,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3,780 mg/kg/6 week- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Other changes 		BMERE* 12,77,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 79,-,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,4-DIAMINOANISOLE-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a hair dye component
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 19, 1978


REFERENCES:

CODEN
REFERENCE
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BMERE* Biomedical Research. (Aligarh M.A. Qayyum For Scientific Publishers Of India) V.1- 1990-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JIDOAA Experimental Animals. Jikken Dobutso Iho. (Nippon Jikken Dobutsu Gakkai, c/o Keio Gijuku Daigaku Igakubu Jikken Dobutsu Senta, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.1- 1952-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as a hair dye component

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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