The Registry of Toxic Effects of Chemical Substances

Anisole

RTECS #: BZ8050000

CAS #: 100-66-3

UPDATE: February 2004 MW: 108.15 MF: C7H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzene, methoxy
  2. Ether, methyl phenyl
  3. Methoxybenzene
  1. Methyl phenyl ether
  2. Phenyl methyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,243,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human lymphocyte 25 µmol/L RCOCB8 54,133,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 200 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,289,1994
inhalation
mouse 		lethal concentration (50 percent kill): 3,021 mg/m3/2 hour N/R GTPZAB 28(6),43,1984
inhalation
mouse 		lethal concentration (50 percent kill): 3,020 mg/m3/2 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes 		VCVGK* -,289,1994
inhalation
mouse 		lowest published toxic concentration: 1,880 mg/m3 Behavioral: General anesthetic VCVGK* -,289,1994
inhalation
rat 		lethal concentration (50 percent kill): >5,000 mg/m3 N/R GTPZAB 28(6),43,1984
inhalation
rat 		lethal concentration (50 percent kill): 8,949 mg/m3/2 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes 		VCVGK* -,289,1994
intraperitoneal
rat 		lowest published lethal dose: 500 mg/kg N/R JAFCAU 17,497,1969
oral
guinea pig 		lethal dose (50 percent kill): 2,500 mg/kg N/R VCVGK* -,289,1994
oral
mouse 		lethal dose (50 percent kill): 2,800 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JPETAB 88,400,1946
oral
mouse 		lethal dose (50 percent kill): 2,900 mg/kg N/R VCVGK* -,289,1994
oral
rat 		lethal dose (50 percent kill): 3,700 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Hematuria 		TXAPA9 6,378,1964
oral
rat 		lethal dose (50 percent kill): 5,290 mg/kg N/R VCVGK* -,289,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 mg/m3/122 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,289,1994
oral
rat 		lowest published toxic dose: 31,740 mg/kg/30 day- intermittent Liver: Changes in liver weight VCVGK* -,289,1994
oral
rabbit 		lowest published toxic dose: 1,500 mg/kg/15 day- intermittent Liver: Liver function tests impaired

Blood: Changes in other cell count (unspecified) 		VCVGK* -,289,1994
oral
rabbit 		lowest published toxic dose: 118.3 mg/kg/26 week- intermittent Endocrine: Other changes VCVGK* -,290,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1533;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 2;
Total Number of Employees Exposed 469


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in perfumery and in organic synthesis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in perfumery and in organic synthesis

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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