The Registry of Toxic Effects of Chemical Substances
o - Anisidine, 5 - methyl - |
UPDATE: May 2005 | MW: 137.20 | MF: C8H11NO |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
100 mg/24 hour
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moderate
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85JCAE -,721,1986
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skin | rabbit
500 mg/24 hour
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mild
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85JCAE -,721,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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DNA damage
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oral | mouse
595 mg/kg
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MUREAV 412,155,1998
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mutation in microorganisms
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Escherichia coli
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2 mg/plate (+enzymatic activation step)
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ENMUDM 7(Suppl 5),1,1985
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mutation in microorganisms
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Salmonella typhimurium
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62,500 ng (+enzymatic activation step)
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ENMUDM 7(Suppl 5),1,1985
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morphological transform
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mouse
fibroblast
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5 mg/L/21 day (-enzymatic activation step)
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EMMUEG 37,231,2001
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morphological transform
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rat
embryo
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31 µg/plate
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JJATDK 1,190,1981
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | mouse
lowest published toxic dose: 355 gm/kg/92 week- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
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oral | mouse
toxic dose : 1,607 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
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oral | mouse
toxic dose : 2,961 gm/kg/92 week- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
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oral | rat
lowest published toxic dose: 364 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Brain and Coverings: Tumors Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
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oral | rat
toxic dose : 182 gm/kg/2 year- continuous
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Tumorigenic: Neoplastic by RTECS criteria | Brain and Coverings: Tumors Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
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oral | rat
toxic dose : 3,640 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
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oral | rat
toxic dose : 7,280 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
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oral | rat
toxic dose : 364 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Olfaction: Tumors
ANTRD4 1,279,1981
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oral | rat
toxic dose : 437 gm/kg/2 year- continuous
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Tumorigenic: Carcinogenic by RTECS criteria | Olfaction: Tumors
ANTRD4 1,279,1981
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lethal dose (50 percent kill): 1,450 mg/kg
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N/R
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HURC** -,-,1972
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review
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Animal Sufficient Evidence
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IMEMDT 27,91,1982
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International Agency for Research on Cancer (IARC) Cancer Review
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Human No Adequate Data
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IMEMDT 27,91,1982
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 2B
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IMSUDL 7,56,1987
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TOXICOLOGY REVIEW
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MUREAV 543,201,2003
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Exposure Limit - AUSTRIA
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Carcinogen, JAN1999
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Occupational Exposure Limit - FINLAND
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Carcinogen, JAN1993
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Occupational Exposure Limit - FRANCE
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Carcinogen, JAN1993
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Occupational Exposure Limit - GERMANY
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Carcinogen, JAN1999
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Occupational Exposure Limit - SWITZERLAND
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Carcinogen, JAN1999
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as a dye, pigment and printing ink
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat
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NCITR* NCI-TR-142,1979
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NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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REFERENCES:
CODEN
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REFERENCE
85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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ANTRD4
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Anticancer Research. (5 Argyropoulou St., Kato Patissia, Athens 907, Greece) V.1- 1981-
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EMMUEG
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Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.10- 1987-
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ENMUDM
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Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see
EMMUEG.
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HURC**
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Huntingdon Research Center Reports. (Box 527, Brooklandville, MD 21022)
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IMEMDT
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IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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IMSUDL
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IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210) No.1- 1979-
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JJATDK
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JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W.
Sussex PO19 1UD, UK) V.1- 1981-
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NCITR*
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National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205.
For publisher information, see NTPTR*.
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