The Registry of Toxic Effects of Chemical Substances
p - Anisidine |
UPDATE: November 2004 | MW: 123.17 | MF: C7H9NO |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster ovary | 160 mg/L | EMMUEG 10(Suppl 10),1,1987 |
DNA damage | mouse lymphocyte | 202 痠ol/L | MUREAV 203,155,1988 |
DNA damage | mouse other cell types | 32 mg/L/24 hour (-enzymatic activation step) | MUREAV 541,9,2003 |
DNA inhibition |
oral mouse | 200 mg/kg | MUREAV 46,305,1977 |
DNA repair | Escherichia coli | 39 mmol/L | MUREAV 272,145,1992 |
host-mediated assay |
mouse
Escherichia coli | 780 mg/kg | MUREAV 272,161,1992 |
mutation in microorganisms | mouse lymphocyte | 196 痠ol/L (+enzymatic activation step) | MUTAEX 3,193,1988 |
mutation in microorganisms | Salmonella typhimurium | 1 mg/plate (-enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
mutation in mammalian somatic cells | mouse lymphocyte | 392 痠ol/L | MUTAEX 3,193,1988 |
sister chromatid exchange | hamster ovary | 14 mg/L | EMMUEG 10(Suppl 10),1,1987 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal mouse | lethal dose (50 percent kill): 806 mg/kg | N/R | JMCMAR 17,900,1974 |
intraperitoneal rat | lethal dose (50 percent kill): 1,400 mg/kg | N/R | AGGHAR 15,447,1957 |
oral mouse | lethal dose (50 percent kill): 1,410 mg/kg |
Eye: Other eye effects Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia | ATDAEI 1,184,1992 |
oral rat | lethal dose (50 percent kill): 1,320 mg/kg | N/R | TLSMA6 128,14,1979 |
oral rabbit | lethal dose (50 percent kill): 2,900 mg/kg |
Kidney, Ureter, and Bladder: Other changes Blood: Normocytic anemia Blood: Other changes | IMEMDT 27,63,1982 |
skin rat | lethal dose (50 percent kill): 3,200 mg/kg | N/R | AGGHAR 15,447,1957 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 10 mg/m3/4 hour/1 year- intermittent |
Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Blood: Pigmented or nucleated red blood cells Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 4,91,1962 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.5 mg/m3 (skin) | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Not Classifiable as a Human Carcinogen | DTLVS* TLV/BEI,2003 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 27,63,1982 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 3 | IMSUDL 7,56,1987 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 0.1 ppm (0.5 mg/m3) (skin) | DTLWS* 3,10,1973 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 0.5 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 0.1 ppm (0.5 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JAN1993 | |
Occupational Exposure Limit - FRANCE | VME 0.1 ppm (0.5 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 0.1 ppm (0.5 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - INDIA | time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - JAPAN | Occupational Exposure Limit Skin, JAN1999 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 0.5 mg/m3, Skin, 2003 | |
Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 0.5 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 1 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 0.1 ppm (0.5 mg/m3), KZG- week 0.2 ppm (1 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 0.1 ppm (0.53 mg/m3), SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; Not Classifiable as a Human Carcinogen | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-ANISIDINE-air | 10 hour time-weighted average 0.5 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used for the production of dyes and pharmaceuticals | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Anisidine, 2514 |
REFERENCES: | |
CODEN |
REFERENCE |
AGGHAR | Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. |
ATDAEI | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
DTLWS* | "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
ENMUDM | Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
IMSUDL | IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- |
JMCMAR | Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
MUTAEX | Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
TLSMA6 | Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued. |
TPKVAL | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- |