The Registry of Toxic Effects of Chemical Substances

o - Anisidine

RTECS #: BZ5410000

CAS #: 90-04-0

UPDATE: May 2004 MW: 123.17 MF: C7H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. o - Aminoanisole
  2. 2 - Aminoanisole
  3. 1 - Amino - 2 - methoxybenzene
  4. 2 - Anisidine
  5. o - Anisidine (ACGIH:OSHA)
  6. Benzenamine, 2 - methoxy - (9CI)
  7. 2 - Methoxy - 1 - aminobenzene
  1. o - Methoxyaniline
  2. 2 - Methoxyaniline
  3. 2 - Methoxybenzenamine
  4. o - Methoxyphenylamine
  5. 2 - Methoxyphenylamine
  6. o - Anisylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1,200 mg/L EMMUEG 10(Suppl 10),1,1987
DNA damage mouse lymphocyte 1,250 µmol/L MUREAV 203,155,1988
DNA damage oral
mouse 		690 mg/kg MUREAV 412,155,1998
DNA inhibition oral
mouse 		200 mg/kg MUREAV 46,305,1977
DNA repair Escherichia coli 31,600 µmol/L MUREAV 272,145,1992
host-mediated assay mouse
Escherichia coli 		310 mg/kg MUREAV 272,161,1992
mutation in microorganisms mouse lymphocyte 1 mmol/L (+enzymatic activation step) MUTAEX 3,193,1988
mutation in microorganisms Salmonella typhimurium 333 µg/plate (-enzymatic activation step) IMEMDT 27,63,1982
gene conversion and mitotic recombination Drosophila melanogaster 1 mmol/L MUREAV 514,193,2002
mutation in mammalian somatic cells mouse lymphocyte 2 mmol/L MUTAEX 3,193,1988
sister chromatid exchange hamster ovary 38 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
wild bird 		lethal dose (50 percent kill): 422 mg/kg N/R AECTCV 12,355,1983
oral
mouse 		lethal dose (50 percent kill): 1,400 mg/kg Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes 		IMEMDT 27,63,1982
oral
rat 		lethal dose (50 percent kill): 1,150 mg/kg N/R TLSMA6 128,14,1979
oral
rabbit 		lethal dose (50 percent kill): 870 mg/kg Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes 		IMEMDT 27,63,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,49,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,63,1982
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,49,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 73,49,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.5 mg/m3) (skin) DTLWS* 3,10,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.5 mg/m3), Skin, continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - INDIA time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit Skin, 2B Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.5 mg/m3), KZG- week 0.2 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.51 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-ANISIDINE-air Carcinogen;
10 hour time-weighted average 0.5 mg/m3 (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8302;
Number of Industries 1;
Total Number of Facilities 50;
Number of Occupations 3;
Total Number of Employees Exposed 705


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for the production of dyes, pharmaceuticals and textile-processing chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Anisidine, 2514


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.

Used for the production of dyes, pharmaceuticals and textile-processing chemicals

RTECS Compound Description:
   Tumorigen
   Mutagen

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