The Registry of Toxic Effects of Chemical Substances

Aniline, p - nitro -

RTECS #: BY7000000

CAS #: 100-01-6

UPDATE: February 2005 MW: 138.14 MF: C6H6N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 4 - nitrobenzene
  2. 4 - Nitraniline
  3. 4 - Nitroaniline
  4. 4 - Nitrobenzenamine
  5. Aniline, 4 - nitro -
  6. Azoamine Red ZH
  7. Azoic Diazo Component 37
  8. Benzenamine, 4 - nitro - (9CI)
  9. C.I. 37035
  10. C.I. Azoic Diazo Component 37
  11. C.I. Developer 17
  12. Developer P
  13. Devol Red GG
  14. Diazo Fast Red GG
  15. Fast Red 2G Base
  16. Fast Red Base 2J
  17. Fast Red Base GG
  1. Fast Red GG Base
  2. Fast Red MP Base
  3. Fast Red P Base
  4. NCI - C60786
  5. Naphtoelan Red GG Base
  6. Nitrazol CF Extra
  7. PNA
  8. RCRA waste number P077
  9. Red 2G Base
  10. Shinnippon Fast Red GG Base
  11. p - Aminonitrobenzene
  12. p - Nitraniline
  13. p - Nitroanilina (Polish)
  14. p - Nitroaniline
  15. p - Nitroaniline (ACGIH:OSHA)
  16. p - Nitrophenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 173 mg/L EMMUEG 27,67,1996
DNA repair Bacillus subtilis 5 mg/disc MUREAV 170,11,1986
mutation in microorganisms other microorganisms 1,500 µg/L (-enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms Salmonella typhimurium 333 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) MUREAV 44,9,1977
phage inhibition capacity Escherichia coli 100 mmol/L MDMIAZ 31,11,1979
sister chromatid exchange hamster ovary 1,600 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 9,600 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TCMUD8 7,29,1987
oral
rat 		lowest published toxic dose: 1,764 mg/kg (14 week male/14 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) FAATDF 15,607,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 51,500 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors 		NTPTR* NTP-TR-418,1993
oral
mouse 		lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Angiosarcoma

Blood: Normocytic anemia 		NTIS** PB94-104528


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): 800 mg/kg N/R IGIBA5 15,151,1966
intraperitoneal
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R NTIS** AD691-490
intraperitoneal
rat 		lowest published lethal dose: 600 mg/kg N/R 85GMAT -,92,1982
intravenous
mammal (species unspecified) 		lowest published lethal dose: 40 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia XPHBAO 271,34,1941
oral
wild bird 		lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
guinea pig 		lethal dose (50 percent kill): 450 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		VKMGA7 6,89,1966
oral
mouse 		lethal dose (50 percent kill): 810 mg/kg N/R TXAPA9 42,417,1977
oral
quail 		lethal dose (50 percent kill): 1 gm/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 750 mg/kg N/R CEHYAN 23,168,1978
skin
guinea pig 		lethal dose (50 percent kill): >500 mg/kg N/R NTIS** OTS0572389


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 80 mg/m3/6 hour/4 week- intermittent Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in leukocyte (WBC) count 		FAATDF 6,618,1986
inhalation
rat 		lowest published toxic concentration: 510 mg/m3/6 hour/2 week- intermittent Blood: Other hemolysis with or without anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count 		NTIS** OTS0546534
oral
mouse 		lowest published toxic dose: 300 mg/kg/14 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count 		NTPTR* NTP-TR-418,1993
oral
mouse 		lowest published toxic dose: 650 mg/kg/13 week- intermittent Liver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in spleen 		NTPTR* NTP-TR-418,1993
oral
rat 		lowest published toxic dose: 6,750 mg/kg/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0533716
oral
rat 		lowest published toxic dose: 2,700 mg/kg/90 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in spleen

Blood: Changes in other cell count (unspecified) 		TOXID9 3,128,1983
oral
rat 		lowest published toxic dose: 120 mg/kg/30 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 50(4),82,1985
oral
rat 		lowest published toxic dose: 180 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count 		GISAAA 50(4),82,1985
oral
rat 		lowest published toxic dose: 6,552 mg/kg/2 year- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Endocrine: Changes in spleen weight 		FAATDF 15,607,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 mg/m3 (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (6 mg/m3) (skin) DTLVS* 3,182,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (6 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (6 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (6 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (6 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 ppm (6 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (6 mg/m3), short term exposure limit 3 ppm (18 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 1 ppm (6 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6 mg/m3, Skin, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 6 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-NITROANILINE-air 10 hour time-weighted average 3 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3131;
Number of Industries 4;
Total Number of Facilities 281;
Number of Occupations 10;
Total Number of Employees Exposed 2,814
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3131;
Number of Industries 2;
Total Number of Facilities 48;
Number of Occupations 7;
Total Number of Employees Exposed 1,448;
Total Number of Female Employees Exposed 262


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in the preparation of dyes and in the manufacture of antioxidants
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: p-Nitroaniline, 5033
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
CEHYAN Ceskoslovenska Hygiena. Czechoslovak Hygiene. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1956-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IGIBA5 Igiena. (Bucharest, Romania) V.5-23, 1956-74(?). For publisher information, see RABIDH.
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VKMGA7 Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene. (Kiev, USSR) V.6, 1966. For publisher information, see GNAMAP.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used in the preparation of dyes and in the manufacture of antioxidants

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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