The Registry of Toxic Effects of Chemical Substances

Aniline, o - nitro -

RTECS #: BY6650000

CAS #: 88-74-4

UPDATE: July 2000 MW: 138.14 MF: C6H6N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 2 - nitrobenzene
  2. Azoene Fast Orange GR Base
  3. Azogene Fast Orange GR
  4. Azoic Diazo Component 6
  5. Benzene, 1 - amino - 2 - nitro -
  6. Brentamine Fast Orange GR Base
  7. C.I. 37025
  8. C.I. Azoic Diazo Component 6
  9. Devol Orange B
  10. Diazo Fast Orange GR
  11. Fast Orange Base GR
  1. Fast Orange Base JR
  2. Fast Orange GR Base
  3. Fast Orange O Base
  4. Hiltonil Fast Orange GR Base
  5. o - Nitraniline
  6. 2 - Nitroaniline
  7. Orange Base Ciba II
  8. Orange Base IRGA II
  9. Orange Salt Ciba II
  10. Orange Salt IRGA II


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 10 mmol/L MUREAV 320,273,1994
DNA repair Bacillus subtilis 5 mg/disc MUREAV 170,11,1986
DNA repair Escherichia coli 15,500 ng/well MUREAV 133,161,1984
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) MUREAV 44,9,1977
micronucleus test oral
mouse 		738 mg/kg MUREAV 320,273,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >2,529 mg/m3/4 hour Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease 		NTIS** OTS0558766
intraperitoneal
rat 		lowest published lethal dose: 800 mg/kg N/R 85GMAT -,91,1982
oral
wild bird 		lethal dose (50 percent kill): 750 mg/kg N/R AECTCV 12,355,1983
oral
guinea pig 		lethal dose (50 percent kill): 2,350 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		VKMGA7 6,89,1966
oral
mouse 		lethal dose (50 percent kill): 1,070 mg/kg N/R GTPZAB 25(8),50,1981
oral
quail 		lethal dose (50 percent kill): 750 mg/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 1,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		VKMGA7 6,89,1966
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 9,441 mg/kg N/R GISAAA 48(6),22,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84091;
Number of Industries 1;
Total Number of Facilities 28;
Number of Occupations 2;
Total Number of Employees Exposed 336
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84091;
Number of Industries 2;
Total Number of Facilities 54;
Number of Occupations 3;
Total Number of Employees Exposed 1,612;
Total Number of Female Employees Exposed 455


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as dye intermediate, synthesis of SULFAQUINOXALINE, o-PHENYLENEDIAMINE, BENZOTRIAZOLE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VKMGA7 Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene. (Kiev, USSR) V.6, 1966. For publisher information, see GNAMAP.

Used as dye intermediate, synthesis of SULFAQUINOXALINE, o-PHENYLENEDIAMINE, BENZOTRIAZOLE

RTECS Compound Description:
   Mutagen

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