The Registry of Toxic Effects of Chemical Substances

Aniline, N - methyl - N,2,4,6 - tetranitro -

RTECS #: BY6300000

CAS #: 479-45-8

UPDATE: November 2004 MW: 287.17 MF: C7H5N5O8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,4,6 - Tetryl
  2. 2,4,6 - Trinitrophenyl - N - methylnitramine
  3. 2,4,6 - Trinitrophenylmethylnitramine
  4. 2,4,6 - Trinitrophenylmethylnitramine (OSHA)
  5. Benzenamine, N - methyl - N,2,4,6 - tetranitro - (9CI)
  6. CE
  7. N - Methyl - N,2,4,6 - tetranitroaniline
  8. N - Methyl - N,2,4,6 - tetranitrobenzenamine
  9. N - Methyl - N - 2,4,6 - tetranitroaniline
  1. Nitramine
  2. Nitramine (indicator)
  3. Picrylmethylnitramine
  4. Picrylnitromethylamine
  5. Tetralit
  6. Tetralite
  7. Tetril
  8. Tetryl
  9. Tetryl (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe ATDAEI 1,167,1992


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Neurospora crassa 5 µg/plate (-enzymatic activation step) TOLED5 5,11,1980
mutation in microorganisms Salmonella typhimurium 2,500 ng/plate (+/-enzymatic activation step) TOLED5 5,11,1980
mutation in microorganisms Salmonella typhimurium 25 µg/plate/90 minute (+enzymatic activation step) MUREAV 490,45,2001
gene conversion and mitotic recombination Saccharomyes cerevisiae 5 µg/plate TOLED5 5,11,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ATDAEI 1,167,1992
oral
rat 		lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ATDAEI 1,167,1992
subcutaneous
dog 		lowest published lethal dose: 5 gm/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Interstitial nephritis 		JIDHAN 2,247,1920
skin
rabbit 		lethal dose : >2 gm/kg N/R ATDAEI 1,167,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5,580 mg/kg/90 day- continuous Blood: Other changes

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 15,202,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1.5 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1.5 mg/m3 (skin) DTLVS* 3,255,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1.5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1.5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1.5 mg/m3, short term exposure limit 3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 1.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 1.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1.5 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1.5 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1.5 mg/m3, short term exposure limit 3 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1.5 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1.5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRYL-air 10 hour time-weighted average 1.5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264271/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an explosive in detonators and primers and as a booster charge for military devices
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as an explosive in detonators and primers and as a booster charge for military devices

RTECS Compound Description:
   Mutagen
   Primary Irritant

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