The Registry of Toxic Effects of Chemical Substances

Aniline, N - methyl -

RTECS #: BY4550000

CAS #: 100-61-8

UPDATE: November 2004 MW: 107.17 MF: C7H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (Methylamino) benzene
  2. Anilinomethane
  3. Benzenamine, N - methyl - (9CI)
  4. Methylaniline
  5. Methylphenylamine
  6. Monomethyl aniline (OSHA)
  7. Monomethylaniline
  1. N - Methyl aniline
  2. N - Methylaminobenzene
  3. N - Methylaniline (ACGIH)
  4. N - Methylbenzenamine
  5. N - Methylphenylamine
  6. N - Monomethylaniline
  7. N - Phenylmethylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
cat 		lowest published lethal dose: 24 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		JIHTAB 31,1,1949
intravenous
rabbit 		lowest published lethal dose: 24 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		JIHTAB 31,1,1949
oral
guinea pig 		lowest published lethal dose: 1,200 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		XPHBAO 271,16,1941
oral
rabbit 		lowest published lethal dose: 280 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		JIHTAB 31,1,1949
subcutaneous
guinea pig 		lowest published lethal dose: 1,200 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		XPHBAO 271,16,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 300 µg/m3/24 hour/14 week- continuous Behavioral: Muscle contraction or spasticity

Liver: Liver function tests impaired

Blood: Methemoglobinemia- Carboxhemoglobinemia 		GISAAA 34(3),7,1969


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (9 mg/m3) (skin) DTLVS* 3,174,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 ppm (9 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 ppm (9 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 ppm (9 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 ppm (9 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 2 ppm (9 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 ppm (2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2.2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.25 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 ppm (2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 2 ppm (9 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (2.2 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MONOMETHYL ANILINE-air 10 hour time-weighted average 0.5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3740;
Number of Industries 1;
Total Number of Facilities 82;
Number of Occupations 1;
Total Number of Employees Exposed 82


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Monomethylaniline, 3511


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

RTECS Compound Description:
   Mutagen

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