The Registry of Toxic Effects of Chemical Substances

Aniline, p - chloro -

RTECS #: BX0700000

CAS #: 106-47-8

UPDATE: November 2004 MW: 127.58 MF: C6H6ClN


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 4 - Aminochlorobenzene
  2. 1 - Amino - 4 - chlorobenzene
  3. 4 - Amino - 1 - chlorobenzene
  4. Benzeneamine, 4 - chloro
  5. 4 - Chloranilin (Czech)
  6. p - Chloraniline
  7. p - Chloroaniline
  1. 4 - Chloroaniline
  2. 4 - Chlorobenzenamine
  3. p - Chlorophenylamine
  4. 4 - Chlorophenylamine
  5. NCI - C02039
  6. RCRA waste number P024
  7. Aniline, 4 - chloro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg/24 hour severe 85JCAE -,610,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,610,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage oral
mouse 		200 mg/kg MUREAV 440,1,1999
DNA repair Escherichia coli 5 mg/L JJIND8 62,873,1979
unscheduled DNA synthesis rat liver 5 mg/L MUREAV 97,359,1982
mutation in microorganisms Aspergillus nidulans 200 mg/L (-enzymatic activation step) CJMIAZ 16,369,1970
mutation in microorganisms mouse lymphocyte 15,600 µg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in mammalian somatic cells mouse lymphocyte 1,520 µmol/L MUTAEX 3,193,1988
morphological transform hamster embryo 10 µg/L NCIMAV 58,243,1981
morphological transform mouse embryo 800 µg/L EMMUEG 12,21,1988
morphological transform rat embryo 14,500 ng/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5,150 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		FCTOD7 29,119,1991
oral
mouse 		toxic dose : 328 gm/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors 		NCITR* NCI-TR-189,1979
oral
rat 		lowest published toxic dose: 9,270 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors 		FCTOD7 29,119,1991
oral
rat 		toxic dose : 14 gm/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors

Blood: Tumors 		NCITR* NCI-TR-189,1979
oral
rat 		toxic dose : 18,200 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Tumors 		FCTOD7 25,619,1987


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (12 percent kill): 250 mg/m3/6 hour N/R 85GMAT -,34,1982
inhalation
rat 		lethal concentration (50 percent kill): 2,340 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		NTIS** OTS0546450
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R TSCAT* OTS 206512
intraperitoneal
rat 		lethal dose (50 percent kill): 420 mg/kg N/R AGGHAR 15,447,1957
intravenous
dog 		lowest published lethal dose: 100 mg/kg Lung, Thorax, or Respiration: Other changes AEPPAE 244,387,1963
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R TXAPA9 21,315,1972
oral
guinea pig 		lethal dose (50 percent kill): 350 mg/kg N/R 85GMAT -,34,1982
oral
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
oral
quail 		lethal dose (50 percent kill): 237 mg/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 300 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression 		GISAAA 32(7),13,1967
subcutaneous
cat 		lowest published lethal dose: 125 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other hemolysis with or without anemia 		AHBAAM 110,12,1933
skin
cat 		lethal dose (50 percent kill): 239 mg/kg N/R GTPZAB 13(5),29,1969
skin
rat 		lethal dose (50 percent kill): 3,200 mg/kg N/R AGGHAR 15,447,1957
skin
rabbit 		lethal dose (50 percent kill): 360 mg/kg Skin: After topical application: Primary irritation AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 30 µg/m3/24 hour/80 day- continuous Behavioral: Muscle contraction or spasticity GISAAA 35(4),44,1970
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/4 hour/17 week- intermittent Behavioral: Aggression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count 		GTPZAB 13(5),29,1969
oral
rat 		lowest published toxic dose: 3,367 mg/kg/13 week- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Kidney, Ureter, and Bladder: Other changes in urine composition 		GISAAA 32(7),13,1967
subcutaneous
rat 		lowest published toxic dose: 1 gm/kg/10 day- intermittent Blood: Other changes FATOAO 35,108,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 57,305,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,305,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 57,305,1993
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Skin, Carcinogen, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND Skin, Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a chemical intermediate, dye, pigment and printing ink
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat NCITR* NCI-TR-189,1979


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CJMIAZ Canadian Journal of Microbiology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1954-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a chemical intermediate, dye, pigment and printing ink

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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