The Registry of Toxic Effects of Chemical Substances

Aniline, o - chloro -

RTECS #: BX0525000

CAS #: 95-51-2

UPDATE: August 2004 MW: 127.58 MF: C6H6ClN


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 2 - chlorobenzene
  2. Benzenamine, 2 - chloro - (9CI)
  3. o - Chloraniline
  4. o - Chloroaniline
  1. 2 - Chloroaniline
  2. 2 - Chlorobenzenamine
  3. Fast Yellow GC Base


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Escherichia coli 500 µg/L JJIND8 62,873,1979
mutation in microorganisms Aspergillus nidulans 200 mg/L (-enzymatic activation step) CJMIAZ 16,369,1970
mutation in mammalian somatic cells hamster lung 600 µg/L BLFSBY 39,359,1986
specific locus test mouse lymphocyte 300 mg/L EMMUEG 17,196,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 797 ppm/4 hour Eye: Corneal damage

Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis 		NTIS** OTS0571625
oral
mouse 		lethal dose (50 percent kill): 256 mg/kg N/R GTPZAB 13(5),29,1969
subcutaneous
cat 		lowest published lethal dose: 310 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		AHBAAM 110,12,1933
skin
cat 		lethal dose (50 percent kill): 222 mg/kg N/R GTPZAB 13(5),29,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,230 mg/m3/4 hour/2 week- intermittent Eye: Other eye effects

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0571672
oral
mouse 		lowest published toxic dose: 14,560 mg/kg/13 week- intermittent Endocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOXID9 14,394,1994
oral
mouse 		lowest published toxic dose: 910 mg/kg/13 week- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TOSCF2 69,234,2002
oral
mouse 		lowest published toxic dose: 7,280 mg/kg/13 week- intermittent Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOSCF2 69,234,2002
oral
mouse 		lowest published toxic dose: 14,560 mg/kg/13 week- intermittent Cardiac: Changes in heart weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOSCF2 69,234,2002
oral
rat 		lowest published toxic dose: 14,560 mg/kg/13 week- intermittent Endocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOXID9 14,394,1994
oral
rat 		lowest published toxic dose: 120 mg/kg/3 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TOSCF2 69,234,2002
oral
rat 		lowest published toxic dose: 1,820 mg/kg/13 week- intermittent Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOSCF2 69,234,2002
oral
rat 		lowest published toxic dose: 7,280 mg/kg/13 week- intermittent Cardiac: Changes in heart weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOSCF2 69,234,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND time-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83962;
Number of Industries 2;
Total Number of Facilities 38;
Number of Occupations 3;
Total Number of Employees Exposed 18,138


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as dye, pesticide, and rubber chemicals intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-43, October 2000


REFERENCES:

CODEN
REFERENCE
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
CJMIAZ Canadian Journal of Microbiology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1954-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as dye, pesticide, and rubber chemicals intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen

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