The Registry of Toxic Effects of Chemical Substances

Aniline, N,N - dimethyl - p - phenylazo -

RTECS #: BX7350000

CAS #: 60-11-7

UPDATE: November 2004 MW: 225.32 MF: C14H15N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 4 - (N,N - Dimethylamino) azobenzene
  2. 4 - (Phenylazo) - N,N - dimethylaniline
  3. 4 - Dimethylaminoazobenzene (OSHA)
  4. 4 - Dimethylaminoazobenzol
  5. 4 - Dimethylaminophenylazobenzene
  6. Atul Fast Yellow R
  7. Azobenzene, p - dimethylamino -
  8. Benzenamine, N,N - dimethyl - 4 - (phenylazo) - (9CI)
  9. Benzeneazodimethylaniline
  10. Brilliant Fast Oil Yellow
  11. Brilliant Fast Spirit Yellow
  12. Brilliant Fast Yellow
  13. Brilliant Oil Yellow
  14. Butter Yellow
  15. C.I. 11020
  16. C.I. Solvent Yellow 2
  17. Cerasine Yellow GG
  18. DAB
  19. DAB (carcinogen)
  20. DMAB
  21. Dimethyl Yellow
  22. Dimethyl Yellow Analar
  23. Dimethyl Yellow N,N - dimethylaniline
  24. Enial Yellow 2G
  25. Fast Oil Yellow B
  26. Fast Yellow
  27. Fat Yellow
  28. Fat Yellow A
  29. Fat Yellow AD OO
  30. Fat Yellow ES
  31. Fat Yellow ES Extra
  32. Fat Yellow Extra Conc.
  33. Fat Yellow R
  34. Fat Yellow R (8186)
  35. Grasal Brilliant Yellow
  36. Iketon Yellow Extra
  37. Jaune de beurre (French)
  38. Methyl Yellow
  39. N,N - Dimethyl - 4 - (phenylazo) benzamine
  40. N,N - Dimethyl - 4 - (phenylazo) benzenamine
  41. N,N - Dimethyl - 4 - aminoazobenzene
  42. N,N - Dimethyl - p - aminoazobenzene
  43. N,N - Dimethyl - p - azoaniline
  1. N,N - Dimethyl - p - phenylazoaniline
  2. Oil Yellow 20
  3. Oil Yellow 2625
  4. Oil Yellow 2G
  5. Oil Yellow 7463
  6. Oil Yellow BB
  7. Oil Yellow D
  8. Oil Yellow DN
  9. Oil Yellow FF
  10. Oil Yellow FN
  11. Oil Yellow G
  12. Oil Yellow G - 2
  13. Oil Yellow GG
  14. Oil Yellow GR
  15. Oil Yellow II
  16. Oil Yellow N
  17. Oil Yellow PEL
  18. Oil Yellow S
  19. Oleal Yellow 2G
  20. Organol Yellow ADM
  21. Orient Oil Yellow GG
  22. P.D.A.B.
  23. Petrol Yellow WT
  24. RCRA waste number U093
  25. Resinol Yellow GR
  26. Resoform Yellow GGA
  27. Silotras Yellow T2G
  28. Somalia Yellow A
  29. Stear Yellow JB
  30. Sudan GG
  31. Sudan Yellow
  32. Sudan Yellow GG
  33. Sudan Yellow GGA
  34. Toyo Oil Yellow G
  35. USAF EK - 338
  36. Waxoline Yellow AD
  37. Waxoline Yellow ADS
  38. Yellow G soluble in grease
  39. Zlut maselna (Czech)
  40. Zlut rozpoustedlova 2 (Czech)
  41. p - Dimethylamino - azobenzol (German)
  42. p - Dimethylaminoazobenzen (Czech)
  43. p - Dimethylaminoazobenzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium 		600 mg/kg NATUAS 249,850,1974
cytogenetic analysis oral
rat 		756 mg/kg/3 week JNCIAM 54,1245,1975
DNA adduct intraperitoneal
mouse 		120 mg/kg CNREA8 40,2493,1980
DNA adduct skin
mouse 		192 µmol/kg CRNGDP 5,231,1984
DNA adduct oral
rat 		300 mg/kg CNREA8 36,4647,1976
DNA adduct intraperitoneal
rat 		150 mg/kg NATUAS 213,1206,1967
DNA damage intraperitoneal
mouse 		200 mg/kg MUREAV 493,39,2001
DNA damage oral
mouse 		500 mg/kg MUREAV 493,39,2001
DNA inhibition human HeLa cell 100 µmol/L MUREAV 92,427,1982
DNA inhibition intraperitoneal
mouse 		20 gm/kg ARGEAR 51,605,1981
DNA inhibition oral
mouse 		100 mg/kg MUREAV 46,305,1977
DNA repair Escherichia coli 80 mg/L MUREAV 119,135,1983
DNA repair Saccharomyes cerevisiae 600 mg/L PMRSDJ 1,502,1981
unscheduled DNA synthesis hamster liver 1 µmol/L ENMUDM 5,1,1983
unscheduled DNA synthesis human HeLa cell 10 nmol/L CNREA8 38,2621,1978
unscheduled DNA synthesis human fibroblast 4 mg/L PMRSDJ 1,528,1981
unscheduled DNA synthesis mouse liver 1 µmol/L GANNA2 72,930,1981
unscheduled DNA synthesis rat liver 1 µmol/L CNREA8 46,1654,1986
unscheduled DNA synthesis rat liver 1 µmol/L JJCREP 78,505,1987
host-mediated assay mouse
Salmonella typhimurium 		255 mg/kg/3 hour MUREAV 45,291,1977
mutation in microorganisms Escherichia coli 200 mg/L (+enzymatic activation step) PMRSDJ 1,396,1981
mutation in microorganisms mouse lymphocyte 6,250 µg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms Salmonella typhimurium 5 mg/plate (+enzymatic activation step) AEMIDF 42,641,1981
mutation in microorganisms Salmonella typhimurium 33 µg/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
micronucleus test intraperitoneal
mouse 		6,400 µg/kg PMRSDJ 1,686,1981
gene conversion and mitotic recombination oral
Drosophila melanogaster 		2.0 mmol/L/48 hour MUTAEX 16,385,2001
gene conversion and mitotic recombination Saccharomyes cerevisiae 5 mg/L PMRSDJ 1,491,1981
mutation in mammalian somatic cells mouse lymphocyte 89 µmol/L MUREAV 110,147,1983
morphological transform intraperitoneal
hamster 		500 mg/kg ARPAAQ 95,380,1973
morphological transform hamster embryo 50 µg/L JJIND8 67,1303,1981
morphological transform hamster kidney 25 mg/L PMRSDJ 1,638,1981
morphological transform mouse embryo 89 µmol/L MUREAV 152,113,1985
morphological transform mouse fibroblast 1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform non-mammalian species other cell types 250 µg/L AOHYA3 20,297,1977
morphological transform rat embryo 12 mg/L JJIND8 67,1303,1981
sister chromatid exchange intraperitoneal
mouse 		29 mg/kg MUREAV 108,225,1983
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 50 mg/L PMRSDJ 1,468,1981
sperm morphology intraperitoneal
mouse 		3 gm/kg/5 day- intermittent PMRSDJ 1,712,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 3 gm/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) PMRSDJ 1,712,1981
subcutaneous
mouse 		lowest published toxic dose: 200 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system OFAJAE 36,195,1960


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 3,830 µg/kg Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		CNREA8 44,2540,1984
intraperitoneal
mouse 		toxic dose : 11 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		CNREA8 44,2540,1984
multiple
mouse 		lowest published toxic dose: 400 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application 		CNREA8 1,397,1941
oral
dog 		lowest published toxic dose: 9,600 mg/kg/69 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		JNCIAM 13,1497,1953
oral
hamster 		lowest published toxic dose: 9,600 mg/kg/42 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Change in gall bladder structure or function

Blood: Other hemolysis with or without anemia 		ARPAAQ 71,566,1961
oral
rat 		lowest published toxic dose: 5,426 mg/kg/17 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		CBINA8 53,107,1985
oral
rat 		toxic dose : 2,600 mg/kg/13 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		CNREA8 17,387,1957
oral
rat 		toxic dose : 13 gm/kg/53 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		MEXPAG 4,1,1961
oral
rat 		toxic dose : 1,920 mg/kg/14 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		CNREA8 5,235,1945
oral
rat 		toxic dose : 1,800 mg/kg/14 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		CNREA8 8,141,1948
oral
rat 		toxic dose : 2,331 mg/kg/7 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		KTUNAA 32,229,1979
oral
rat 		toxic dose : 17,200 mg/kg/17 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		ARPAAQ 81,162,1966
oral
rat 		toxic dose : 8,316 mg/kg/33 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		JPBAA7 59,1,1947
oral
rat 		toxic dose : 3,990 mg/kg/19 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Consolidation

Liver: Tumors 		GANNA2 63,131,1972
oral
rat 		toxic dose : 800 mg/kg/64 day- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		ZEKBAI 61,327,1956
subcutaneous
mouse 		lowest published toxic dose: 4,000 mg/kg (15-21 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors 		BEXBAN 78,1402,1974
skin
rat 		lowest published toxic dose: 1,440 mg/kg/90 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 26,2406,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 230 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		CNREA8 34,2274,1974
intraperitoneal
rat 		lethal dose (50 percent kill): 230 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		CNREA8 34,2274,1974
oral
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R GANNA2 54,455,1963
oral
rat 		lethal dose (50 percent kill): 200 mg/kg N/R ZEKBAI 69,103,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 20,000 mg/kg/40 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		BJCAAI 86,630,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 8,125,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 8,125,1975
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ALLVAR 50,77,1962
TOXICOLOGY REVIEW
BJCAAI 6,270,1952
TOXICOLOGY REVIEW
ADCSAJ 13,271,1970
TOXICOLOGY REVIEW
JONUAI 44,345,1951
TOXICOLOGY REVIEW
BLFSBY 24,129,1983


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1115 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) cancer suspect agent CFRGBR 29,1910.1015,1987
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-DIMETHYLAMINOAZOBENZENE-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1015 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26175;
Number of Industries 2;
Total Number of Facilities 29;
Number of Occupations 2;
Total Number of Employees Exposed 42
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 26175;
Number of Industries 2;
Total Number of Facilities 56;
Number of Occupations 2;
Total Number of Employees Exposed 1,453;
Total Number of Female Employees Exposed 996


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for coloring polishes and wax products, POLYSTYRENE, petrol, soap, and as an indicator
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950-
AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976-
ALLVAR Alimentation et la Vie. (Societe Scientifique d'Hygiene Alimentaire, 16, rue de l'Estrapade, 75005 Paris, France) V.39- 1951-
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928-
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS.
KTUNAA K'at'ollik Taehak Uihakpu Nonmunjip. Journal of Catholic Medical College. (Catholic Medical College, Graduate School, Seoul 135, S. Korea) V.1- 1957-
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
OFAJAE Okajimas Folia Anatomica Japonica. (Keio Univ., School of Medicine, Dept. of Anatomy, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.14- 1936-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7.

Used for coloring polishes and wax products, POLYSTYRENE, petrol, soap, and as an indicator

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

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