The Registry of Toxic Effects of Chemical Substances

Aniline, N,N - dimethyl - p - nitroso -

RTECS #: BX7175000

CAS #: 138-89-6

UPDATE: January 1997 MW: 150.20 MF: C8H10N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Accelerine
  2. Benzenamine, N,N - dimethyl - 4 - nitroso - (9CI)
  3. p - (Dimethylamino) nitrosobenzene
  4. 4 - (Dimethylamino) nitrosobenzene
  5. N,N - Dimethyl - p - nitrosoaniline
  6. N,N - Dimethyl - 4 - nitrosobenzenamine
  7. Dimethyl (p - nitrosophenyl) amine
  1. NCI - C01821
  2. NDMA
  3. Paranitrosodimethylanilide
  4. p - Nitroso - N,N - dimethylaniline
  5. 4 - Nitrosodimethylaniline
  6. Ultra Brilliant Blue P


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 10 µg/plate (+enzymatic activation step) ENMUDM 8(Suppl 7),1,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 7,300 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Blood: Lymphoma including Hodgkin's disease 		PUOMA5 46,68,1968


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published lethal dose: 650 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria 		JIDHAN 13,87,1931


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
PUOMA5 Proceedings of the University of Otago Medical School. (Otago Medical School Research Soc., Box 913, Dunedin, New Zealand) V.1- 1922-

Used as an industrial chemical, chemical intermediate, in manufacture of plastics, resins

RTECS Compound Description:
   Tumorigen
   Mutagen

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