The Registry of Toxic Effects of Chemical Substances

Aniline, m - chloro -

RTECS #: BX0350000

CAS #: 108-42-9

UPDATE: August 2004 MW: 127.58 MF: C6H6ClN


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. m - Aminochlorobenzene
  2. 1 - Amino - 3 - chlorobenzene
  3. Benzenamine, 3 - chloro - (9CI)
  4. 3 - Chlooranilinen (Dutch)
  5. m - Chloraniline
  6. m - Chloroaniline
  7. 3 - Chloroaniline
  1. 3 - Chlorobenzenamine
  2. m - Chlorophenylamine
  3. 3 - Chlorophenylamine
  4. 3 - Cloroaniline (Italian)
  5. Fast Orange GC Base
  6. Orange GC Base


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Aspergillus nidulans 200 mg/L (-enzymatic activation step) CJMIAZ 16,369,1970
mutation in mammalian somatic cells hamster lung 300 µg/L BLFSBY 39,359,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 550 mg/m3/4 hour N/R 85GMAT -,34,1982
inhalation
rat 		lethal dose (50 percent kill): 150 ppm/4 hour Eye: Corneal damage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		NTIS** OTS0555316
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R TSCAT* OTS 206512
intraperitoneal
rat 		lethal dose (50 percent kill): 200 mg/kg N/R TSCAT* OTS 206512
intravenous
dog 		lowest published lethal dose: 50 mg/kg Lung, Thorax, or Respiration: Other changes AEPPAE 244,387,1963
oral
guinea pig 		lethal dose (50 percent kill): 250 mg/kg N/R GISAAA 31(12),6,1966
oral
mouse 		lethal dose (50 percent kill): 334 mg/kg N/R GTPZAB 13(5),29,1969
oral
rat 		lethal dose (50 percent kill): 256 mg/kg N/R GISAAA 31(12),6,1966
subcutaneous
cat 		lowest published lethal dose: 125 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		AHBAAM 110,12,1933
skin
cat 		lethal dose (50 percent kill): 223 mg/kg N/R GTPZAB 13(5),29,1969
skin
guinea pig 		lethal dose (50 percent kill): 100 mg/kg N/R TSCAT* OTS 206512
skin
rat 		lethal dose (50 percent kill): 250 mg/kg N/R 85GMAT -,34,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 14,560 mg/kg/13 week- intermittent Endocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOXID9 14,394,1994
oral
mouse 		lowest published toxic dose: 910 mg/kg/13 week- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TOSCF2 69,234,2002
oral
mouse 		lowest published toxic dose: 1,820 mg/kg/13 week- intermittent Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOSCF2 69,234,2002
oral
mouse 		lowest published toxic dose: 14,560 mg/kg/13 week- intermittent Cardiac: Changes in heart weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOSCF2 69,234,2002
oral
rat 		lowest published toxic dose: 10 gm/kg/13 week- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Kidney, Ureter, and Bladder: Other changes in urine composition 		GISAAA 32(7),13,1967
oral
rat 		lowest published toxic dose: 6,125 mg/kg/35 week- intermittent Brain and Coverings: Recordings from specific areas of CNS GISAAA 31(12),6,1966
oral
rat 		lowest published toxic dose: 30 mg/kg/3 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TOSCF2 69,234,2002
oral
rat 		lowest published toxic dose: 14,560 mg/kg/13 week- intermittent Cardiac: Changes in heart weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 69,234,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND time-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4029;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 851;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as dye, pesticide, and pharmaceutical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0193-8687
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-43, October 2000


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
CJMIAZ Canadian Journal of Microbiology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1954-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

Used as dye, pesticide, and pharmaceutical intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen

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