The Registry of Toxic Effects of Chemical Substances

Aniline, 3,4 - dichloro -

RTECS #: BX2625000

CAS #: 95-76-1

UPDATE: July 2000 MW: 162.02 MF: C6H5Cl2N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 3,4 - dichlorobenzene
  2. Benzenamine, 3,4 - dichloro - (9CI)
  3. 3,4 - DCA
  4. 3,4 - Dichloranilin
  1. 3,4 - Dichloraniline
  2. 3,4 - Dichloroaniline
  3. 4,5 - Dichloroaniline
  4. 3,4 - Dichlorobenzenamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg/24 hour severe 85JCAE -,612,1986
eye
rabbit 		10 mg mild TSCAT* OTS 215198
skin
rabbit 		2 mg/24 hour severe 85JCAE -,612,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Aspergillus nidulans 200 mg/L (-enzymatic activation step) CJMIAZ 16,369,1970
sister chromatid exchange human lymphocyte 125 µmol/L MUREAV 226,197,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 65 mg/m3/4 hour N/R TSCAT* OTS 215198
intraperitoneal
mouse 		lethal dose (50 percent kill): 310 mg/kg Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes 		LPPTAK 27,306,1979
intraperitoneal
rat 		lethal dose (50 percent kill): 280 mg/kg Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes 		LPPTAK 27,306,1979
oral
wild bird 		lethal dose (50 percent kill): 237 mg/kg N/R AECTCV 12,355,1983
oral
guinea pig 		lethal dose (50 percent kill): 675 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		GISAAA 33(4),8,1968
oral
mouse 		lethal dose (50 percent kill): 740 mg/kg N/R GTPZAB 13(5),29,1969
oral
rat 		lethal dose (50 percent kill): 545 mg/kg N/R TSCAT* OTS 215198
oral
rabbit 		lethal dose (50 percent kill): 675 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		GISAAA 33(4),8,1968
skin
cat 		lethal dose (50 percent kill): 700 mg/kg N/R GTPZAB 13(5),29,1969
skin
rabbit 		lowest published lethal dose: 300 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0571586


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 30 µg/m3/24 hour/14 week- continuous Behavioral: Muscle contraction or spasticity GISAAA 35(4),44,1970
oral
rat 		lowest published toxic dose: 6,370 mg/kg/13 week- intermittent Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 33(4),8,1968
oral
rat 		lowest published toxic dose: 3,640 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count 		GISAAA 33(4),8,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4030;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 851;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as dye and pesticide intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
CJMIAZ Canadian Journal of Microbiology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1954-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
LPPTAK Labo-Pharma-Problemes et Techniques. (Editions de Sante, 19 rue Louis-le-Grand, 75002 Paris, France) V.12- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

Used as dye and pesticide intermediate

RTECS Compound Description:
   Mutagen
   Primary Irritant

 Click Here for Additional Information about RTECS