The Registry of Toxic Effects of Chemical Substances

Aniline, 2 - chloro - 4 - nitro -

RTECS #: BX1400000

CAS #: 121-87-9

UPDATE: October 1997 MW: 172.58 MF: C6H5ClN2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 2 - chloro - 4 - nitrobenzene
  2. o - Chloro - p - nitroaniline
  3. 2 - Chloro - 4 - nitroaniline
  1. 4 - Nitro - 2 - chloroaniline
  2. Ocpna


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+/-enzymatic activation step) SAIGBL 29,34,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 500 mg/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea 		CBCCT* 5,337,1953
intravenous
mouse 		lethal dose (50 percent kill): 56 mg/kg N/R CBCCT* 6,138,1954
oral
guinea pig 		lethal dose (50 percent kill): 1,800 mg/kg Behavioral: General anesthetic NTIS** OTS0536149
oral
mouse 		lethal dose (50 percent kill): 1,250 mg/kg N/R GTPZAB 25(8),50,1981
oral
rat 		lethal dose (50 percent kill): 6,430 mg/kg N/R GTPZAB 25(8),50,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0882;
Number of Industries 12;
Total Number of Facilities 708;
Number of Occupations 9;
Total Number of Employees Exposed 2,937
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0882;
Number of Industries 1;
Total Number of Facilities 25;
Number of Occupations 2;
Total Number of Employees Exposed 737


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-

RTECS Compound Description:
   Mutagen

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