The Registry of Toxic Effects of Chemical Substances

Ammonium, tetramethyl - , chloride

RTECS #: BS7700000

CAS #: 75-57-0

UPDATE: September 1998 MW: 109.62 MF: C4H12N•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Methanaminium, N,N,N - trimethyl - , chloride (9CI)
  2. Tetramethylammonium chloride
  3. Tetramine chloride
  1. USAF AN - 8
  2. N,N,N - Trimethylmethanaminium chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 mg/kg Behavioral: Somnolence (general depressed activity) NTIS** OTS0536975
intraperitoneal
rat 		lethal dose (50 percent kill): 10 mg/kg Behavioral: Somnolence (general depressed activity)

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Cyanosis 		NTIS** OTS0536975
oral
mouse 		lowest published lethal dose: 125 mg/kg N/R JPMSAE 69,327,1980
oral
rat 		lethal dose (50 percent kill): 50 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair 		NTIS** OTS0536975
subcutaneous
frog 		lowest published lethal dose: 2 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Cardiac: Other changes 		SAPHAO 10,201,1900
subcutaneous
mouse 		lethal dose (50 percent kill): 40 mg/kg N/R NTIS** ORNL-5576
subcutaneous
rabbit 		lowest published lethal dose: 6 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes 		AIPTAK 7,183,1900
unreported route
guinea pig 		lowest published lethal dose: 20 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		AIPTAK 7,183,1900
unreported route
mouse 		lowest published lethal dose: 20 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		AIPTAK 7,183,1900


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4596;
Number of Industries 2;
Total Number of Facilities 41;
Number of Occupations 2;
Total Number of Employees Exposed 2,840;
Total Number of Female Employees Exposed 1,777


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX.

RTECS Compound Description:
   Drug

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