The Registry of Toxic Effects of Chemical Substances

Ammonium, (2 - chloroethyl) trimethyl - , chloride

RTECS #: BP5250000

CAS #: 999-81-5

UPDATE: August 2003 MW: 158.09 MF: C5H13ClN•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. AC 38555
  2. Antywylegacz
  3. Barleyquat B
  4. Bercema CCC
  5. CCC (plant growth regulant)
  6. 2 - Chloraethyl - trimethylammoniumchlorid (German)
  7. Chlorcholinchlorid (Czech)
  8. Chlorcholine chloride
  9. Chlormequat chloride
  10. Chlorocholine chloride
  11. (beta - Chloroethyl) trimethylammonium chloride
  12. (2 - Chloroethyl) trimethylammonium chloride
  13. 2 - Chloro - N,N,N - trimethylethanaminium chloride
  14. 60 - CS - 16
  15. Cycocel
  1. Cycocel Extra
  2. EI 38,555
  3. Ethanaminium, 2 - chloro - N,N,N - trimethyl - , chloride (9CI)
  4. Hico CCC
  5. Hormocel - 2CCC
  6. Increcel
  7. Lihocin
  8. NCI - C02960
  9. Premix
  10. Retacel
  11. Stabilan
  12. WR 62
  13. Zar
  14. Trimethyl - beta - chlorethylammoniumchlorid (Czech)
  15. TUR


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour mild 85JCAE -,616,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition intravaginal
mouse 		5 pph JIDEAE 62,378,1974
mutation in microorganisms Escherichia coli 500 mmol/L/30 minute (-enzymatic activation step) MUREAV 40,229,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 7,100 mg/kg/78 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >5,200 mg/m3/4 hour N/R PEMNDP 9,149,1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 62 mg/kg N/R ABMGAJ 27,663,1971
intraperitoneal
rat 		lethal dose (50 percent kill): 64 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		ABMGAJ 33,89,1974
intravenous
cat 		lowest published lethal dose: 1,200 µg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
intravenous
human 		lowest published lethal dose: 1 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
intravenous
mouse 		lethal dose (50 percent kill): 7 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
intravenous
rat 		lethal dose (50 percent kill): 12,500 µg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
intravenous
rabbit 		lowest published lethal dose: 4 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
oral
domestic bird 		lethal dose (50 percent kill): 261 mg/kg N/R PEMNDP 9,149,1991
oral
cat 		lethal dose (50 percent kill): 7 mg/kg N/R AXVMAW 24,1049,1970
oral
chicken 		lethal dose (50 percent kill): 920 mg/kg N/R PEMNDP 9,149,1991
oral
dog 		lethal dose (50 percent kill): 50 mg/kg N/R AXVMAW 24,1049,1970
oral
human 		lowest published lethal dose: 10 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression 		AXVMAW 31,527,1977
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 670 mg/kg N/R GUCHAZ 6,104,1973
oral
mouse 		lethal dose (50 percent kill): 54 mg/kg N/R ABMGAJ 27,663,1971
oral
quail 		lethal dose (50 percent kill): 555 mg/kg N/R PEMNDP 9,149,1991
oral
rat 		lethal dose (50 percent kill): 600 mg/kg N/R GISAAA 36(11),33,1971
oral
rabbit 		lethal dose (50 percent kill): 70 mg/kg N/R AXVMAW 31,527,1977
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 440 mg/kg N/R GUCHAZ 6,104,1973
skin
rat 		lethal dose (50 percent kill): >4 gm/kg N/R PEMNDP 9,149,1991
skin
rabbit 		lethal dose (50 percent kill): 232 mg/kg N/R WRPCA2 9,119,1970
unreported route
mouse 		lethal dose (50 percent kill): 560 mg/kg N/R VINIT* #4758-80
unreported route
rat 		lethal dose (50 percent kill): 780 mg/kg N/R VINIT* #4758-80


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,920 mg/kg/24 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response 		TXCYAC 30,103,1984
oral
rat 		lowest published toxic dose: 7,920 mg/kg/72 day- intermittent Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		GISAAA 36(11),33,1971
oral
rat 		lowest published toxic dose: 15,600 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		GISAAA 43(4),8,1978
oral
rabbit 		lowest published toxic dose: 1,092 mg/kg/39 week- intermittent Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight 		GISAAA 36(11),33,1971


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,223,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4610;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 2;
Total Number of Employees Exposed 107


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, emulsifier, agricultural chemical and pesticide
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-158,1979


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications.
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a solvent, emulsifier, agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 39394-21-3
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