The Registry of Toxic Effects of Chemical Substances

Ammonium, benzyldimethyl (2 - (2 - (p - (1,1,3,3 - tetramethylbutyl) phenoxy) ethoxy) ethyl) - ,chloride

RTECS #: BO7175000

CAS #: 121-54-0

UPDATE: July 2002 MW: 448.15 MF: C27H42NO2•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Anti - germ 77
  2. Antiseptol
  3. Antiseptol (quarternary compound)
  4. Benzethonium chloride
  5. Benzethonium chloride 1622
  6. Benzyldimethyl - p - (1,1,3,3 - tetramethylbutyl) phenoxyethoxy - ethylammonium chloride
  7. Benzyldimethyl (2 - (2 - (p - (1,1,3,3 - tetramethylbutyl) phenoxy) ethoxy) ethyl) ammonium chloride
  8. BZT
  9. Diapp
  10. Diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride
  11. Disilyn
  12. Hyamine
  1. Hyamine 1622
  2. NCI - C61494
  3. Phemeride
  4. Phemerol
  5. Phemerol chloride
  6. Phemithyn
  7. Polymine D
  8. Quatrachlor
  9. Solamin
  10. Solamine
  11. p - tert - Octylphenoxyethoxyethyldimethylbenzylammonium chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		30 µg severe PSTGAW 20,16,1953


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Escherichia coli 1,500 ng/well MUREAV 133,161,1984
sister chromatid exchange hamster embryo 1 mg/L SHIGAZ 74,1365,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 104 mg/kg/1 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		CTOXAO 4,185,1971


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 7,813 µg/kg N/R JACTDZ 4(5),65,1985
intraperitoneal
rat 		lethal dose (50 percent kill): 16,500 µg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		FSDZD4 9,729,1983
intravenous
mouse 		lethal dose (50 percent kill): 30 mg/kg N/R JAPMA8 40,267,1951
intravenous
rat 		lethal dose (50 percent kill): 19 mg/kg Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Hematuria

Blood: Changes in cell count (unspecified) 		SCHSAV 30,147,1954
oral
mouse 		lethal dose (50 percent kill): 338 mg/kg N/R PSEBAA 120,511,1965
oral
rat 		lethal dose (50 percent kill): 368 mg/kg N/R PSEBAA 120,511,1965
subcutaneous
rat 		lethal dose (50 percent kill): 119 mg/kg N/R NTIS** PB195-158
unreported route
rat 		lethal dose (50 percent kill): 420 mg/kg N/R 85KYAH 11,167,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraspinal
pig 		lowest published toxic dose: 13 mg/kg/7 day- intermittent Spinal Cord: Other degenerative changes RAPMFX 24,146,1999
oral
rat 		lowest published toxic dose: 182 gm/kg/2 year- continuous Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 109,422,1953
subcutaneous
rat 		lowest published toxic dose: 312 mg/kg/1 year- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain CTOXAO 4(2),185,1971
skin
mouse 		lowest published toxic dose: 1,200 mg/kg/16 day- intermittent Cardiac: Changes in heart weight

Endocrine: Changes in thymus weight

Skin: After systemic exposure: Dermatitis, other 		NTPTR* NTP-TR-438,1995
skin
mouse 		lowest published toxic dose: 101 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, other NTPTR* NTP-TR-438,1995
skin
rat 		lowest published toxic dose: 60 mg/kg/16 day- intermittent Endocrine: Changes in thymus weight

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-438,1995
skin
rat 		lowest published toxic dose: 203 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, other NTPTR* NTP-TR-438,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JACTDZ 4(5),65,1985


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 25830;
Number of Industries 15;
Total Number of Facilities 2,975;
Number of Occupations 26;
Total Number of Employees Exposed 26,546
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 25830;
Number of Industries 11;
Total Number of Facilities 1,657;
Number of Occupations 20;
Total Number of Employees Exposed 26,949;
Total Number of Female Employees Exposed 18,054


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a topical anti-infective agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (derm);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FSDZD4 Fukuoka Shika Daigaku Gakkai Zasshi. Journal of Fukuoka Dental College. (700 Ta, O-aza, Sawara-ku, Fukuoka 814-01, Japan) V.1- 1974-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
PSTGAW Proceedings of the Scientific Section of the Toilet Goods Association. (Washington, DC) No.1-48, 1944-67. Discontinued.
RAPMFX Regional Anesthesia and Pain Medicine. (Churchill Livingstone, The Curtis Center, Independence Square West, Philadelphia, PA 19106) V.23- 1998-
SCHSAV Soap and Chemical Specialties. (New York, NY) V.30-47, 1954-71. For publisher information, see SCCSC8.
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-

Used as a topical anti-infective agent

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Primary Irritant

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