The Registry of Toxic Effects of Chemical Substances

Aluminum sulfate (2:3)

RTECS #: BD1700000

CAS #: 10043-01-3

UPDATE: November 2004 MW: 342.14 MF: O12S3•2Al


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Alum
  2. Aluminum alum
  3. Aluminum sulfate
  4. Aluminum trisulfate
  1. Cake alum
  2. Dialuminum sulphate
  3. Dialuminum trisulfate
  4. Sulfuric acid, aluminum salt (3:2)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		10 mg/24 hour severe NTIS** OTS0571939


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 20 mg/L MUREAV 244,179,1990
cytogenetic analysis oral
rat 		762 mg/kg/7 day- continuous CYTBAI 66,105,1991
micronucleus test human lymphocyte 20 mg/L MUREAV 244,179,1990
other mutation test systems human lymphocyte 20 mg/L MUREAV 244,179,1990
other mutation test systems oral
rat 		762 mg/kg/7 day- continuous CYTBAI 66,105,1991
sister chromatid exchange human lymphocyte 20 mg/L MUREAV 244,179,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 800 mg/kg (10-13 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		BNBIDY 59,136,1993
intratesticular
rat 		lowest published toxic dose: 27,371 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964
subcutaneous
mouse 		lowest published toxic dose: 27,371 µg/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 274 mg/kg N/R COREAF 256,1043,1963
oral
mouse 		lethal dose (50 percent kill): 6,207 mg/kg N/R BJIMAG 23,305,1966
unreported route
guinea pig 		lethal dose (50 percent kill): 490 mg/kg N/R GISAAA 43(4),12,1978
unreported route
mouse 		lethal dose (50 percent kill): 520 mg/kg N/R GISAAA 43(4),12,1978
unreported route
rat 		lethal dose (50 percent kill): 410 mg/kg N/R GISAAA 43(4),12,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1.1 gm/kg/13 week- intermittent Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOLED5 132,131,2002
oral
rat 		lowest published toxic dose: 10,138 mg/kg/8 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: P 		BJIMAG 23,305,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg(Al)/m3 DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,295,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg(Al)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg(Al)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 2 mg(Al)/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 2 mg(Al)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 2 mg(Al)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg(Al)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg(Al)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 04620;
Number of Industries 136;
Total Number of Facilities 21,057;
Number of Occupations 92;
Total Number of Employees Exposed 104,804
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1197;
Number of Industries 11;
Total Number of Facilities 2,133;
Number of Occupations 15;
Total Number of Employees Exposed 23,355;
Total Number of Female Employees Exposed 8,416
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8589;
Number of Industries 2;
Total Number of Facilities 394;
Number of Occupations 3;
Total Number of Employees Exposed 1,496
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 04620;
Number of Industries 117;
Total Number of Facilities 16,815;
Number of Occupations 111;
Total Number of Employees Exposed 212,242;
Total Number of Female Employees Exposed 57,674


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in paper industry, in waste and water treatment, in deodorants, in flame-retardants
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
BNBIDY Behavioral and Neural Biology. (Academic Press, Inc., 111 5th Ave., New York, NY 10003) V.25- 1979-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used in paper industry, in waste and water treatment, in deodorants, in flame-retardants

Top 50 chemical production: 2.18 billions lbs in 1992, 2.37 billions in 1991

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRI, 2/77

NIOSH PROFILE (SEWAGE TREATMENT), FIRL, 4/78

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRC, 1/81

FDA-over the counter drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Hormone
   Primary Irritant

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