The Registry of Toxic Effects of Chemical Substances

Aluminum oxide (2:3)

RTECS #: BD1200000

CAS #: 1344-28-1

UPDATE: November 2004 MW: 101.96 MF: Al2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. A 1 (Sorbent)
  2. A1 - 0104 T 3/16''
  3. A1 - 0109 P
  4. A1 - 1401 P (MS)
  5. A1 - 1404 T 3/16''
  6. A1 - 3438 T 1/8''
  7. A1 - 3916 P
  8. A1 - 3945 E 1/16''
  9. A1 - 3970 P
  10. A1 - 3980 T 5/32''
  11. A1 - 4028 T 3/16''
  12. A1 - 4126 E 1/16''
  13. Abramant
  14. Abramax
  15. Abrarex
  16. Abrasit
  17. Activated aluminum oxide
  18. Alcoa F 1
  19. Almite
  20. Alon C
  21. Aloxite
  22. Alumina
  23. Aluminite 37
  24. Aluminum oxide
  25. Aluminum oxide (ACGIH)
  26. Aluminum oxide (Brockmann)
  27. Aluminum sesquioxide
  28. Alumite (oxide)
  29. Alundum (OSHA)
  30. Alundum 600
  31. Brockmann, aluminum oxide
  32. Cab - O - grip
  33. Catapal S
  34. Catapal SB alumina
  35. Compalox
  1. Conopal
  2. Diadur
  3. Dialuminum trioxide
  4. Dispal M
  5. Dispal alumina
  6. Dotment 324
  7. Dotment 358
  8. Dural
  9. Exolon XW 60
  10. F 360 (Alumina)
  11. Faserton
  12. Fasertonerde
  13. G 0 (Oxide)
  14. G 2 (Oxide)
  15. GK (Oxide)
  16. Hypalox II
  17. Jubenon R
  18. KA 101
  19. KHP 2
  20. Ketjen B
  21. LA 6
  22. Lucalox
  23. Ludox CL
  24. Martoxin
  25. Microgrit WCA
  26. PS 1 (Alumina)
  27. Poraminar
  28. Q - Loid A 30
  29. RC 172DBM
  30. alpha - Alumina
  31. alpha - Alumina (ACGIH:OSHA)
  32. alpha - Aluminum oxide
  33. beta - Aluminum oxide
  34. gamma - Aluminum oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 200 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		JJIND8 67,965,1981
implant
rat 		toxic dose : 200 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		IARCCD 8,289,1973
intrapleural
rat 		lowest published toxic dose: 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		BJCAAI 28,173,1973


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): >3,600 mg/kg N/R VCVN1* -,212,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 mg/m3/5 hour/28 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN1* -,213,1988
inhalation
rabbit 		lowest published toxic concentration: 200 mg/m3/5 hour/28 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN1* -,213,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 (E) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
31BYAP -,94,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD NUISANCE PARTICULATES DTLVS* 3,9,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 mg/m3, dust, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 mg(Al)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 6 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 16 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - SWEDEN time-weighted average 4 mg(Al)/m3 (resp. Dust), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 10 mg(Al)/m3 (total dust), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 mg(Al)/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, total inhalable dust, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 4 mg/m3, respirable dust, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 20265;
Number of Industries 267;
Total Number of Facilities 40,757;
Number of Occupations 158;
Total Number of Employees Exposed 513,250
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3152;
Number of Industries 3;
Total Number of Facilities 117;
Number of Occupations 11;
Total Number of Employees Exposed 1,834;
Total Number of Female Employees Exposed 116
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5459;
Number of Industries 27;
Total Number of Facilities 957;
Number of Occupations 19;
Total Number of Employees Exposed 11,287;
Total Number of Female Employees Exposed 899
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5758;
Number of Industries 136;
Total Number of Facilities 12,712;
Number of Occupations 69;
Total Number of Employees Exposed 172,759;
Total Number of Female Employees Exposed 7,087
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9687;
Number of Industries 30;
Total Number of Facilities 1,814;
Number of Occupations 27;
Total Number of Employees Exposed 27,669;
Total Number of Female Employees Exposed 2,616
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 20265;
Number of Industries 333;
Total Number of Facilities 76,124;
Number of Occupations 188;
Total Number of Employees Exposed 1,345,787;
Total Number of Female Employees Exposed 147,525


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a flame-retardant filler and in production of ALUMINUM metal
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aluminum and compounds, as Al, 7013
OSHA ANALYTICAL METHOD #ID109SG
OSHA ANALYTICAL METHOD #ID198SG


REFERENCES:

CODEN
REFERENCE
31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays, International Symposium, 1974," Karbe, E., and J.F. Park, eds., Springer-Verlag New York, Inc., 1974
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as a flame-retardant filler and in production of ALUMINUM metal

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRI, 2/77

NIOSH PROFILE (ALUMINUN REDUCTION PLANTS), FIRL, 4/78

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

NIOSH PROFILE (ALUMINUM and ITS COMPOUNDS), SRC, 1/81

RTECS Compound Description:
   Tumorigen

ALT CAS #: 12522-88-2
ALT CAS #: 53809-96-4
ALT CAS #: 74871-10-6
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