The Registry of Toxic Effects of Chemical Substances
Adiponitrile |
UPDATE: November 2004 | MW: 108.16 | MF: C6H8N2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral rat | lowest published toxic dose: 1,120 mg/kg (6-19 day pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FAATDF 7,33,1986 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lethal concentration (50 percent kill): 1,710 mg/m3/4 hour |
Ear: Change in acuity Lung, Thorax, or Respiration: Other changes | TOXID9 1,76,1981 |
intraperitoneal mouse | lethal dose (50 percent kill): 40 mg/kg | N/R | NTIS** AD691-490 |
oral cat | lethal dose (50 percent kill): 25 mg/kg | N/R | ZAARAM 19,225,1969 |
oral mouse | lethal dose (50 percent kill): 172 mg/kg | N/R | ARTODN 57,88,1985 |
oral rat | lethal dose (50 percent kill): 155 mg/kg | N/R | GISAAA 49(12),40,1984 |
oral rabbit | lethal dose (50 percent kill): 22 mg/kg | N/R | GISAAA 49(12),40,1984 |
subcutaneous guinea pig | lethal dose (50 percent kill): 50 mg/kg | N/R | MELAAD 46,221,1955 |
skin rabbit | lowest published lethal dose: 1 mg/kg | N/R | ZAARAM 19,225,1969 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 493 mg/m3/6 hour/4 week- intermittent |
Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTEHD6 30,199,1990 |
inhalation rat | lowest published toxic concentration: 99 mg/m3/6 hour/13 week- intermittent |
Blood: Pigmented or nucleated red blood cells Blood: Changes in other cell count (unspecified) Blood: Changes in erythrocyte (RBC) count | JTEHD6 30,199,1990 |
inhalation rat | lowest published toxic concentration: 3,028 痢/m3/5 hour/26 week- intermittent |
Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GTPZAB 25(9),64,1981 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 2 ppm (skin) | DTLVS* TLV/BEI,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - RUSSIA | short term exposure limit 10 mg/m3, JAN1993 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 8.8 mg/m3, 2003 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ADIPONITRILE-air | 10 hour time-weighted average 4 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X4253![]() Number of Industries 1; Total Number of Facilities 3; Number of Occupations 2; Total Number of Employees Exposed 478; Total Number of Female Employees Exposed 41 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as very pure polar solvent or chemical intermediate | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
ARTODN | Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
FAATDF | Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
JTEHD6 | Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- |
MELAAD | Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
TOXID9 | Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- |
ZAARAM | Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. |